3-{4-chloro-3-[(1,3,4-trimethyl-1H-pyrazol-5-yl)oxy]phenyl}-N-(pentylsulfonyl)propanamide | 1043915-40-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-{4-chloro-3-[(1,3,4-trimethyl-1H-pyrazol-5-yl)oxy]phenyl}-N-(pentylsulfonyl)propanamide
• 英文别名: 3-[4-chloro-3-(2,4,5-trimethylpyrazol-3-yl)oxyphenyl]-N-pentylsulfonylpropanamide
• CAS: 1043915-40-7
• 化学式: C₂₀H₂₈ClN₃O₄S
• 分子量: 441.979
• InChiKey: UBHCQFZCOWQYBB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  98.7
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• PYRAZOLE COMPOUND
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP2128138A1

  公开（公告）日：2009-12-02

  The present invention aims to provide an agent for the prophylaxis or treatment of diabetes, which has a superior hypoglycemic action, and is associated with a fewer side effects such as body weight gain and the like. The present invention relates to an agent for the prophylaxis or treatment of diabetes comprising a compound represented by the formula: wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof.

  本发明旨在提供一种用于预防或治疗糖尿病的药物，具有优越的降血糖作用，并且与较少的副作用，如体重增加等相关。本发明涉及一种用于预防或治疗糖尿病的药物，包括由以下式表示的化合物：其中每个符号如描述中所定义，或其盐，或其前药。
• 2- [ (2-SUBSTITUTED) -IND0LIZIN-3-YL] -2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS
  申请人：Downham Robert

  公开号：US20100056511A1

  公开（公告）日：2010-03-04

  The invention provides compounds of formula (I), and pharmaceutically acceptable salts thereof wherein: R1, R2, R3, R4, R5, R6, R7, X and X 1 are as defined herein. These compounds are useful in the manufacture of medicaments for use in the prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

  该发明提供了公式（I）的化合物及其药学上可接受的盐，其中：R1，R2，R3，R4，R5，R6，R7，X和X1如本文所定义。这些化合物在制造用于预防或治疗真菌病的药物方面是有用的。公式（I）的化合物及其农业上可接受的盐也可用作农业杀真菌剂。
• 2-[(2-SUBSTITUTED)-IND0LIZIN-3-YL]-2-OXO-ACETAMIDE DERIVATIVES AS ANTIFUNGAL AGENTS
  申请人：F2G Limited

  公开号：EP2097413B1

  公开（公告）日：2013-12-25
• US8604029B2
  申请人：——

  公开号：US8604029B2

  公开（公告）日：2013-12-10