Tobramycin hydrochloride | 95188-93-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Tobramycin hydrochloride
• 英文别名: (2S,3R,4S,5S,6R)-4-amino-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-6-(hydroxymethyl)oxane-3,5-diol;hydrochloride
• CAS: 95188-93-5
• 化学式: C18H38ClN5O9
• 分子量: 504.0
• InChiKey: CVDADWBWFLWJNQ-TWDWGCDDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.87
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  268
• 氢给体数：
  11
• 氢受体数：
  14

文献信息

• Acrylic cements for bone augmentation
  申请人：INOSSIA AB

  公开号：US10603403B2

  公开（公告）日：2020-03-31

  The embodiments relate to an injectable composition for a bone cement material comprising a dry powder component, a liquid component and a modifier configured to modify a Young's modulus of the bone cement material. The modifier is linoleic acid or a derivative thereof and is present in a concentration of 0.1 to 12 v/v of the liquid component.

  本发明涉及一种用于骨水泥材料的可注射组合物，该组合物包括一种干粉成分、一种液体成分和一种用于改变骨水泥材料杨氏模量的改性剂。改性剂为亚油酸或其衍生物，在液体成分中的浓度为 0.1 至 12 v/v。
• Oriented P4HB implants containing antimicrobial agents
  申请人：Tepha, Inc.

  公开号：US10874771B2

  公开（公告）日：2020-12-29

  Oriented resorbable implants made from poly-4-hydroxybutyrate (P4HB) and copolymers thereof, have been developed that contain one or more antimicrobial agents to prevent colonization of the implants, and reduce or prevent the occurrence of infection following implantation in a patient. These oriented implants are particularly suitable for use in procedures where prolonged strength retention is necessary and there is a risk of infection. Coverings and receptacles made from poly-4-hydroxybutyrate and copolymers thereof, containing antimicrobial agents, have also been developed for use with implantable devices to prevent colonization of these devices, and to reduce or prevent the occurrence of infection following implantation of these devices in a patient. These coverings and receptacles may be used to hold, or partially or fully cover, devices such as pacemakers and neurostimulators. Preferably, the coverings and receptacles are made from meshes, non-wovens, films, fibers, and foams, and contain rifampin and minocycline.

  由聚-4-羟基丁酸酯（P4HB）及其共聚物制成的定向可吸收植入物已经研制成功，这种植入物含有一种或多种抗菌剂，可防止植入物的定植，减少或防止植入病人体内后发生感染。这些定向植入物尤其适用于需要长时间保持强度且有感染风险的手术。由聚-4-羟基丁酸及其共聚物制成的、含有抗菌剂的覆盖物和容器也已开发出来，可与植入式装置一起使用，以防止这些装置发生定植，并减少或防止病人植入这些装置后发生感染。这些覆盖物和容器可用于固定、部分或全部覆盖心脏起搏器和神经刺激器等装置。这些覆盖物和容器最好由网格布、无纺布、薄膜、纤维和泡沫制成，并含有利福平和米诺环素。
• Cochleates without metal cations as bridging agents
  申请人：BioPharm Solutions Inc.

  公开号：US20040092727A1

  公开（公告）日：2004-05-13

  This invention provides a cochleate and nano-cochleate systems wherein the agents bridging lipid bilayer are organic multi-valent cations. This invention also provides a method for preparing the cochleate system comprising direct cochleation and hydrogel-isolated procedure. The preparation method comprises using the charge ration between the bridging agents and lipids to control the particle sizes. This cochleate or nano-cochleate system may be used for microencapsulation and delivery of therapeutics wherein the therapeutic agents are loaded in the cochleate structure as the bridging agents between lipid bilayers. Finally, this invention provides other uses of these new cochleate and nano-cochleate systems.

  本发明提供了一种耳蜗酸盐和纳米耳蜗酸盐系统，其中桥接脂质双分子层的制剂为有机多价阳离子。本发明还提供了一种制备耳蜗系统的方法，包括直接耳蜗化和水凝胶隔离程序。制备方法包括利用架桥剂和脂质之间的电荷比来控制颗粒大小。这种蜗牛酸盐或纳米蜗牛酸盐系统可用于治疗药物的微囊化和递送，其中治疗药物作为脂质双分子层之间的桥接剂装载在蜗牛酸盐结构中。最后，本发明还提供了这些新型蜗壳和纳米蜗壳系统的其他用途。
• STABLE METAL ION-LIPID POWDERED PHARMACEUTICAL COMPOSITIONS FOR DRUG DELIVERY AND METHODS OF USE
  申请人：ALLIANCE PHARMACEUTICAL CORPORATION

  公开号：EP1282405A2

  公开（公告）日：2003-02-12
• PULMONARY DELIVERY OF AMINOGLYCOSIDES
  申请人：Nektar Therapeutics

  公开号：EP1458360A1

  公开（公告）日：2004-09-22