6-hydroxyimino-5-oxo-heptanoic acid | 118661-55-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-hydroxyimino-5-oxo-heptanoic acid
• 英文别名: 6-Hydroxyimino-5-oxo-heptansaeure
• CAS: 118661-55-5
• 化学式: C₇H₁₁NO₄
• 分子量: 173.169
• InChiKey: LGEIXWGNCPJGNU-VMPITWQZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.66
• 重原子数：
  12.0
• 可旋转键数：
  5.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  86.96
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  6-hydroxyimino-5-oxo-heptanoic acid 在 硝酸 作用下， 生成 5,6-dioxoheptanoic acid
  参考文献：
  名称：

  Stetter et al., Chemische Berichte, 1958, vol. 91, p. 2882,2884

  摘要：

  DOI：
• 作为产物：
  描述：

  2-甲基-1,3-环己二酮 在 四氢呋喃 、 盐酸 、 sodium nitrite 作用下， 生成 6-hydroxyimino-5-oxo-heptanoic acid
  参考文献：
  名称：

  Improvement in quality of life of dialysis patients during six months of exercise

  摘要：

  Quality of life (QOL) assessment has rapidly become an integral variable of outcome in clinical research; over 1,000 new articles each year are indexed under "quality of life" (1). Despite the proliferation of instruments and the burgeoning theoretical literature devoted to QOL evaluation, no unified approach has been derived for its measurement, and little agreement has been attained on what it means (2). Lack of clarity regarding the definition of QOL has led to several related concepts, namely functional status, life-satisfaction, well-being, and health status, being used interchangeably with QOL (3), further contributing to ambiguity. Compared to the general population, patients with end-stage renal disease (ESRD) experience a poorer QOL (4). Questionnaire-based QOL measurement in ESRD has demonstrated that QOL is best in renal transplantation and worst in unit-based haemodialysis. The main determinants of difference are the physical function domains. QOL in ESRD has traditionally been measured by a number of disease-specific, domain-specific and generic instruments, all exhibiting a fixed design. However, the fixed nature of the aforementioned instruments, is problematic in that what is measured is predetermined and hence may not represent the free choice of the individual whose QOL is assessed (5). Questionnaire-based instruments may not reflect individual priorities.

  DOI：

  10.1111/j.1755-6686.2002.tb00189.x