N-(6-methoxy-2-methylpyridin-3-yl) octanamide | 936329-79-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-(6-methoxy-2-methylpyridin-3-yl) octanamide
• 英文别名: N-(6-methoxy-2-methylpyridin-3-yl)octanamide
• CAS: 936329-79-2
• 化学式: C₁₅H₂₄N₂O₂
• 分子量: 264.368
• InChiKey: URLGSELFHUXGOS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  51.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Substituted Aminopyridines as Fluorescent Reporters for Amide Hydrolases
  申请人：Hammock Bruce D.

  公开号：US20100160391A1

  公开（公告）日：2010-06-24

  The present invention provides conjugates comprising a substituted aminopyridine covalently attached to an organic molecule via an amide bond. Such conjugates find utility as substrates for amide hydrolases, where the substituted aminopyridine acts as a fluorescent reporter of amide hydrolase activity. As a result, the conjugates described herein can advantageously be used in assays to detect amide hydrolase activity based upon measuring the fluorescence of a substituted aminopyridine that is released after amide hydrolysis. The conjugates of the present invention are also particularly useful in screening assays, which enable the identification of inhibitory molecules for amide hydrolases and other enzymes. The identified amide hydrolase inhibitors can be used in the treatment of a variety of diseases and disorders associated with aberrant amide hydrolase activity.

  本发明提供了共轭物，其中一种取代的氨基吡啶通过酰胺键共价连接到有机分子上。这样的共轭物可作为酰胺水解酶的底物，其中取代的氨基吡啶作为酰胺水解酶活性的荧光报告物。因此，本文所述的共轭物可以有利地用于检测基于测量酰胺水解后释放的取代的氨基吡啶的荧光来检测酰胺水解酶活性的测定中。本发明的共轭物也特别适用于筛选测定，可用于识别酰胺水解酶和其他酶的抑制分子。识别的酰胺水解酶抑制剂可用于治疗与异常酰胺水解酶活性相关的各种疾病和障碍。