8-amino-2'-deoxy-adenosine | 13389-09-8

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 8-amino-2'-deoxy-adenosine
• 英文别名: (2R,5R)-5-(6,8-diaminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
• CAS: 13389-09-8
• 化学式: C₁₀H₁₄N₆O₃
• 分子量: 266.26
• InChiKey: KHQCCEUMCUSZKM-YSLANXFLSA-N

物化性质

• 沸点：
  698.2±65.0 °C(Predicted)
• 密度：
  2.08±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  145
• 氢给体数：
  4
• 氢受体数：
  8

安全信息

• 海关编码：
  2934999090

文献信息

• Compositions and methods of synthesis and use of novel nucleic acid structures
  申请人：Eritja Ramon

  公开号：US20060008813A1

  公开（公告）日：2006-01-12

  The present invention is directed to a method to produce 8-amino-2′deoxyadenosine by treating 8-azido-2′deoxyadenosine with an aqueous solution of methylamine or dimethylamine.

  本发明涉及一种通过将8-偶氮基-2'-脱氧腺苷与甲胺或二甲胺的水溶液处理来制备8-氨基-2'-脱氧腺苷的方法。
• Ligand and method for detection of okadaic acid
  申请人：Université de Perpignan

  公开号：EP2770058A1

  公开（公告）日：2014-08-27

  The present invention relates to isolated nucleic acid compounds that bind with high affinity and specificity to okadaic acid. Okadaic acid (OA) is a lipophilic phycotoxin responsible for human intoxication after seafood ingestion. The present invention also relates to the use of said nucleic acid compounds for detecting the presence and for quantitatively assaying okadaic acid in a sample. The present invention also relates to devices and kits comprising said nucleic acid compounds usable for the detection of okadaic acid, and to methods allowing okadaic acid detection in a sample.

  本发明涉及与冈田酸具有高亲和力和特异性结合的分离核酸化合物。冈田酸（OA）是一种亲脂性藻毒素，是人类摄入海产品后中毒的原因。本发明还涉及使用所述核酸化合物检测样品中是否存在冈田酸并对其进行定量分析。本发明还涉及包含可用于检测冈田酸的所述核酸化合物的装置和试剂盒，以及允许在样品中检测冈田酸的方法。
• Method for modifying a template double stranded polynucleotide using a MuA transposase
  申请人：Oxford Nanopore Technologies Ltd.

  公开号：US10570440B2

  公开（公告）日：2020-02-25

  The invention relates to a method for modifying a template double stranded polynucleotide, especially for characterisation using nanopore sequencing. The method produces from the template a plurality of modified double stranded polynucleotides. These modified polynucleotides can then be characterised.

  本发明涉及一种修饰模板双链多核苷酸的方法，特别是用于利用纳米孔测序进行表征。该方法可从模板中产生多个经修饰的双链多核苷酸。然后可以对这些修饰的多核苷酸进行表征。
• Sample preparation method
  申请人：Oxford Nanopore Technologies Ltd.

  公开号：US10669578B2

  公开（公告）日：2020-06-02

  The invention relates to an improved method for characterising a template polynucleotide. The method involves using a polymerase to prepare a modified polynucleotide which makes it easier to characterise than the template polynucleotide.

  本发明涉及一种表征模板多核苷酸的改进方法。该方法包括使用聚合酶制备修饰的多核苷酸，使其比模板多核苷酸更容易表征。
• Genome editing using effector oligonucleotides for therapeutic treatment
  申请人：Shekdar Kambiz

  公开号：US10669547B2

  公开（公告）日：2020-06-02

  The invention provides compositions and methods of making and using effector oligonucleotides, including effector oligonucleotides with greater than one mismatch as compared to its target sequence. These effector oligonucleotides are useful for improving the efficiency of genomic editing as well as providing therapeutic benefits to individuals in need thereof.

  本发明提供了制造和使用效应寡核苷酸的组合物和方法，包括与其靶序列相比存在一个以上错配的效应寡核苷酸。这些效应寡核苷酸有助于提高基因组编辑的效率，并为有需要的个体提供治疗益处。