1-(3-Bromopropyl)-4-methyl-2,5,7-trioxabicyclo[2.2.2]octane | 119114-00-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3-Bromopropyl)-4-methyl-2,5,7-trioxabicyclo[2.2.2]octane
• 英文别名: 1-(3-bromopropyl)-4-methyl-2,5,7-trioxabicyclo[2.2.2]octane
• CAS: 119114-00-0
• 化学式: C₉H₁₅BrO₃
• 分子量: 251.12
• InChiKey: GZUWVTYVSHLMIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF
  申请人：Kozlowski Antoni

  公开号：US20110171716A1

  公开（公告）日：2011-07-14

  Provided herein are water-soluble carbohydrate polymers which are monoderivatized at their reducing terminus, such that the carbohydrate polymers can be selectively conjugated at a single location. Also provided are methods of preparation and conjugation of the monoderivatized carbohydrate polymers.

  本文提供的是水溶性碳水化合物聚合物，它们在其还原端单一衍生化，因此可以在单一位置选择性地结合碳水化合物聚合物。还提供了制备和结合单一衍生化碳水化合物聚合物的方法。
• Method for preparing branched functionalised polymers using branched polyol cores
  申请人：Nektar Therapeutics

  公开号：EP2412744A2

  公开（公告）日：2012-02-01

  A method of preparing a multiarm polymer includes reacting a branched polyol with one or more functionalizing reagents to effect substitution of an ionizable functional group or a protected ionizable functional group, Y, to form a mixture comprising (i) unsubstituted branched polyol containing no Y groups; (ii) a monosubstituted polyol comprising one Y group, and (iii) a multisubstituted polyol (e.g., a disubstituted polyol comprising two Y groups); followed by purifying the mixture to separate the monosubstituted polyol from other species Thereafter, a water-soluble and non-peptidic polymer segment is attached to the monosubstituted branched polyol at the site of at least one of the hydroxyl groups. The invention also provides purified monosubstituted branched polyols and multiarm polymers prepared by the method and polyol precursors for use in the method.

  一种制备多臂聚合物的方法包括将支链多元醇与一种或多种官能化试剂反应，以实现可离子化官能团或受保护的可离子化官能团 Y 的取代，从而形成一种混合物，该混合物包括：(i) 不含 Y 基团的未取代支链多元醇；(ii) 包含一个 Y 基团的单取代多元醇；(iii) 多取代多元醇（例如，包含两个 Y 基团的二取代多元醇）、然后，在至少一个羟基的位置将水溶性非肽聚合物段连接到单取代支化多元醇上。本发明还提供了通过该方法制备的纯化的单取代支链多元醇和多臂聚合物，以及用于该方法的多元醇前体。
• BRANCHED FUNCTIONALIZED POLYMERS USING BRANCHED POLYOL CORES
  申请人：Nektar Therapeutics

  公开号：EP1926768B1

  公开（公告）日：2011-09-14
• METHOD FOR PREPARING BRANCHED FUNCTIONALIZED POLYMERS USING BRANCHED POLYOL CORES
  申请人：Nektar Therapeutics AL, Corporation

  公开号：EP1926768A1

  公开（公告）日：2008-06-04
• Method for Preparing Branched Functionalized Polymers Using Branched Polyol Cores
  申请人：McManus P. Samuel

  公开号：US20070031371A1

  公开（公告）日：2007-02-08

  A method of preparing a multiarm polymer includes reacting a branched polyol with one or more functionalizing reagents to effect substitution of an ionizable functional group or a protected ionizable functional group, Y, to form a mixture comprising (i) unsubstituted branched polyol containing no Y groups; (ii) a monosubstituted polyol comprising one Y group, and (iii) a multisubstituted polyol (e.g., a disubstituted polyol comprising two Y groups); followed by purifying the mixture to separate the monosubstituted polyol from other species Thereafter, a water-soluble and non-peptidic polymer segment is attached to the monosubstituted branched polyol at the site of at least one of the hydroxyl groups. The invention also provides purified monosubstituted branched polyols and multiarm polymers prepared by the method and polyol precursors for use in the method.