2-(2,5,5-trimethyl-3-(4-(4-methylpiperidin-1-ylsulfonyl)benzoyl)-4,5,6,7-tetrahydro-1H-indol-1-yl)acetic acid | 1219449-63-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2,5,5-trimethyl-3-(4-(4-methylpiperidin-1-ylsulfonyl)benzoyl)-4,5,6,7-tetrahydro-1H-indol-1-yl)acetic acid
• 英文别名: 2-[2,5,5-trimethyl-3-[4-(4-methylpiperidin-1-yl)sulfonylbenzoyl]-6,7-dihydro-4H-indol-1-yl]acetic acid
• CAS: 1219449-63-4
• 化学式: C₂₆H₃₄N₂O₅S
• 分子量: 486.632
• InChiKey: ZLCVXLNDVJANKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  105
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• [EN] CRTH2 MODULATORS<br/>[FR] MODULATEURS DE CRTH2
  申请人：IRONWOOD PHARMACEUTICALS INC

  公开号：WO2010039982A1

  公开（公告）日：2010-04-08

  Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I.

  CRTH2的调节剂，特别是CRTH2的拮抗剂，可用于治疗包括哮喘和呼吸道疾病在内的各种疾病。这些化合物属于由式I描述的一类。
• CRTH2 MODULATORS
  申请人：Jia James

  公开号：US20110312945A1

  公开（公告）日：2011-12-22

  Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I

  本发明涉及CRTH2的调节剂，特别是CRTH2的拮抗剂，它们可用于治疗各种疾病，包括哮喘和呼吸系统疾病。这些化合物属于公式I所描述的属。
• METHODS OF TREATING ALOPECIA AND ACNE
  申请人：Ironwood Pharmaceuticals, Inc.

  公开号：US20150080381A1

  公开（公告）日：2015-03-19

  Method of treating alopecia and acne with are disclosed. The compounds fall within described by formula I or II: