Bang3 | 1160852-90-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Bang3
• CAS: 1160852-90-3
• 化学式: C₁₁H₁₄N₂O₂*ClH
• 分子量: 242.705
• InChiKey: AGOCABHCVFNDCB-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-(prop-2-enoxycarbonylamino)propanoic acid 在 三氟乙酸 作用下， 反应 1.0h， 生成 Bang3
  参考文献：
  名称：

  Induction of apoptosis promoted by Bang52; a small molecule that downregulates Bcl-xL

  摘要：

  Cancer cells evade death by over-producing specific proteins that inhibit apoptosis. One such group of proteins is the Bcl-2 family, of which Bcl-x(L) is an important member. This protein binds and inhibits BAK, another protein that promotes apoptosis. While the development of chemical inhibitors that block Bcl-x(L)-BAK association have been the focus of intense research efforts, we demonstrate in this manuscript an alternative strategy to downregulate Bcl-x(L). We have identified a small molecule (Bang52) that induces apoptosis in a lymphoblast-derived cell line by lowering levels of Bcl-x(L). Since Bang52 bears no resemblance to any chemical binder of Bcl-x(L) we believe that degradation of the protein is stimulated by a new type of pathway. These findings highlight a novel approach to the development of small molecules that promote apoptosis. (c) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.067