S-[2-[[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-(dibutylamino)phosphoryl]oxyethyl] 3-hydroxy-2,2-dimethylpropanethioate | 1037070-82-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: S-[2-[[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-(dibutylamino)phosphoryl]oxyethyl] 3-hydroxy-2,2-dimethylpropanethioate
• CAS: 1037070-82-8
• 化学式: C₂₅H₄₅N₄O₉PS
• 分子量: 608.693
• InChiKey: LRHNMNINZKRWPJ-CTMLPALXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  40
• 可旋转键数：
  18
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  210
• 氢给体数：
  4
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  S-(2-(((((2R,3R,4R,5R)-5-(4-((bis(4-methoxyphenyl)(phenyl)methyl)amino)-2-oxopyrimidin-1(2H)-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(dibutylamino)phosphoryl)oxy)ethyl) 2,2-dimethyl-3-(trityloxy)propanethioate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 S-[2-[[(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-3,4-dihydroxy-4-methyloxolan-2-yl]methoxy-(dibutylamino)phosphoryl]oxyethyl] 3-hydroxy-2,2-dimethylpropanethioate
  参考文献：
  名称：

  WO2008/82601

  摘要：

  公开号：

文献信息

• Compounds and Pharmaceutical Compositions for the Treatment of Viral Infections
  申请人：SOMMADOSSI Jean-Pierre

  公开号：US20090238790A2

  公开（公告）日：2009-09-24

  Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗肝脏疾病，包括HCV和/或HBV感染的化合物、组合物和方法。具体来说，披露了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• Compounds and pharmaceutical compositions for the treatment of viral infections
  申请人：Sommadossi Jean-Pierre

  公开号：US20080286230A1

  公开（公告）日：2008-11-20

  Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗肝脏疾病，包括HCV和/或HBV感染的化合物、组合物和方法。具体地，本文公开了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF VIRAL INFECTIONS
  申请人：SOMMADOSSI Jean-Pierre

  公开号：US20110286962A1

  公开（公告）日：2011-11-24

  Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了治疗肝脏疾病，包括HCV和/或HBV感染的化合物、组合物和方法。具体地，揭示了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• Compounds and Pharmaceutical compositions for the treatment of Viral infections
  申请人：Sommadossi Jean-Pierre

  公开号：US20090169504A1

  公开（公告）日：2009-07-02

  Provided herein are compounds, compositions and methods for the treatment of liver disorder, including HCV and/or HBV infections. Specifically, compound and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

  本文提供了用于治疗肝脏疾病，包括HCV和/或HBV感染的化合物，组合物和方法。具体地，公开了核苷衍生物的化合物和组合物，可以单独或与其他抗病毒药物联合使用。
• US20140255339A1
  申请人：——

  公开号：US20140255339A1

  公开（公告）日：2014-09-11