| 1045703-67-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• CAS: 1045703-67-0
• 化学式: C₆₁H₆₃BrO₁₀
• 分子量: 1036.07
• InChiKey: JWVSSRFCWPYAHB-QURBWNRWSA-N

反应信息

• 作为反应物：
  描述：

  6-O-[2-azido-3,6-di-O-benzyl-2-deoxy-α-D-glucopyranosyl]-3,4,5-tri-O-benzyl-1-O-[(2-cyanoethyloxy)-(2-O-benzyloxycarbonyl-3-O-octadecyl-sn-glycerol)phosphono]-2-O-palmitoleoyl-myo-inositol 、 在 silver trifluoromethanesulfonate 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 0.5h， 生成
  参考文献：
  名称：

  Synthesis and biological evaluation of sperm CD52 GPI anchor and related derivatives as binding receptors of pore-forming CAMP factor

  摘要：

  Sperm CD52 GPI anchor and its derivatives containing different carbohydrate chains were prepared, in a highly convergent fashion starting from the same properly protected phospholipidated pseudodisaccharide. Coupling this common key intermediate to various oligosaccharyl donors quickly afforded the framework of the synthetic targets, which was followed by global deprotection to furnish the desired structures. Preliminary studies on the biological properties of the synthetic GPI derivatives indicated that both the intact GPI anchor and the free phospholipidated pseudodisaccharide interacted strongly with CAMP factor, a pore-forming bacterial toxin. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2008.03.033