3-羟基-3-乙基戊二酸 | 52939-72-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 3-羟基-3-乙基戊二酸
• 中文别名: 3-乙基-3-羟基戊二酸
• 英文名称: 3-hydroxy-3-ethylglutaric acid
• 英文别名: 3-ethyl-3-hydroxypentanedioic acid
• CAS: 52939-72-7
• 化学式: C₇H₁₂O₅
• 分子量: 176.169
• InChiKey: AOKDDUPYCZEHIM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2918199090

反应信息

• 作为产物：
  描述：

  4-ethyl-1,6-heptadien-4-ol 在 硫酸 、 双氧水 、 臭氧 、 溶剂黄146 作用下， 生成 3-羟基-3-乙基戊二酸
  参考文献：
  名称：

  3-Alkyl-3-hydroxyglutaric Acids: A New Class of Hypocholesterolemic HMG CoA Reductase Inhibitors. 1

  摘要：

  Derivatives of 3-hydroxy-3-methylglutaric acid (HMG), a portion of the substrate for HMG CoA reductase, were prepared and tested for their inhibitory action against rat liver HMG CoA reductase and for their hypocholesterolemic activity. Structure-dependent competitive inhibition was observed. Optimal structures had a free dicarboxylic acid with an alkyl group of 13-16 carbons at position 3. 3-n-Pentadecyl-3-hydroxyglutaric acid (3j) (IC50 = 50 microM) reduced serum cholesterol in the Triton-treated rat and HMG CoA reductase activity in the 20,25-diazacholesterol-treated rat.

  DOI：

  10.1021/jm50001a011

文献信息

• Pentanedioic acid derivatives
  申请人：G.D. Searle & Co.

  公开号：EP0089674B1

  公开（公告）日：1985-12-27
• LIPID DELIVERY FORMULATIONS
  申请人：Brown Bob D.

  公开号：US20130225663A1

  公开（公告）日：2013-08-29

  The invention provides formulations that contain an immunogenic or immunostimulatory cargo, delivery moiety and/or lipid, and a lipid that functions to reduce or prevent induction in a subject of an immune response which would otherwise occur when the immunogenic or immunostimulatory cargo, delivery moiety and/or lipid is administered to a subject as a component of an appropriate control formulation lacking the immune response reducing lipid. Specific immune response reducing lipids and uses thereof are further provided.
• US9320798B2
  申请人：——

  公开号：US9320798B2

  公开（公告）日：2016-04-26
• [EN] LIPID DELIVERY FORMULATIONS<br/>[FR] FORMULATIONS D'ADMINISTRATION DE LIPIDE
  申请人：DICERNA PHARMACEUTICALS INC

  公开号：WO2011109294A1

  公开（公告）日：2011-09-09

  The invention provides formulations that contain an immunogenic or immunostimulatory cargo, delivery moiety and/or lipid, and a lipid that functions to reduce or prevent induction in a subject of an immune response which would otherwise occur when the immunogenic or immunostimulatory cargo, delivery moiety and/or lipid is administered to a subject as a component of an appropriate control formulation lacking the immune response reducing lipid. Specific immune response reducing lipids and uses thereof are further provided.
• 3-Alkyl-3-hydroxyglutaric Acids: A New Class of Hypocholesterolemic HMG CoA Reductase Inhibitors. 1
  作者：John S. Baran、Ivar Laos、Donna D. Langford、James E. Miller、Charlene Jett、Beatrice Taite、Elaine Rohrbacher

  DOI：10.1021/jm50001a011

  日期：1985.5

  Derivatives of 3-hydroxy-3-methylglutaric acid (HMG), a portion of the substrate for HMG CoA reductase, were prepared and tested for their inhibitory action against rat liver HMG CoA reductase and for their hypocholesterolemic activity. Structure-dependent competitive inhibition was observed. Optimal structures had a free dicarboxylic acid with an alkyl group of 13-16 carbons at position 3. 3-n-Pentadecyl-3-hydroxyglutaric acid (3j) (IC50 = 50 microM) reduced serum cholesterol in the Triton-treated rat and HMG CoA reductase activity in the 20,25-diazacholesterol-treated rat.