1-(3-fluorophenyl)-4-(tributylstannyl)-1H-1,2,3-triazole | 1086032-13-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-(3-fluorophenyl)-4-(tributylstannyl)-1H-1,2,3-triazole
• CAS: 1086032-13-4
• 化学式: C₂₀H₃₂FN₃Sn
• 分子量: 452.203
• InChiKey: XPOJFTZTBPWRDS-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  1-(3-fluorophenyl)-4-(tributylstannyl)-1H-1,2,3-triazole 在 碘 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以516 mg的产率得到1-(3-fluorophenyl)-4-iodo-1H-1,2,3-triazole
  参考文献：
  名称：

  Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist

  摘要：

  We describe here the discovery and the structure-activity relationship (SAR) of a series of 4-(1-Aryl-triazol-4- yl)-tetrahydropyridines as novel mGluR1 antagonists. Our extensive chemical modi. cation of lead compound 2 successfully led to fluoropyridine analogs 7j and 1 with improved in vivo antagonistic activities. Among the evaluated compounds, chemically stable urea analog 1 showed oral antagonistic activity at dose ranges of 10-30 mg/kg in an animal model. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2008.09.060