2-(4-p-chlorophenyl-5-p-hydroxyphenyl-2-oxazolyl-mercapto)-propionic acid | 1026510-63-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(4-p-chlorophenyl-5-p-hydroxyphenyl-2-oxazolyl-mercapto)-propionic acid
• 英文别名: 2-[[4-(4-Chlorophenyl)-5-(4-hydroxyphenyl)-1,3-oxazol-2-yl]sulfanyl]propanoic acid
• CAS: 1026510-63-3
• 化学式: C₁₈H₁₄ClNO₄S
• 分子量: 375.832
• InChiKey: WBCALUIWXXDMQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  109
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Selective Cox-2 Inhibitors
  申请人：Cali M. Brian

  公开号：US20070293542A1

  公开（公告）日：2007-12-20

  The invention features compounds that are inhibitors of COX-2 activity. Certain of the compounds are inhibitors of FAAH activity as well as COX-2 activity. The compounds include a 5-membered or 6-membered substituted or unsubstituted heteroaryl or heterocyclyl ring having one or two heteroatoms selected from the group consisting of O, S, and N that is linked to two substituted or unsubstituted 6-membered aryl or heteroaryl groups that can be the same or different.

  这项发明涉及一种抑制COX-2活性的化合物。其中一些化合物不仅是COX-2活性的抑制剂，还是FAAH活性的抑制剂。这些化合物包括一个带有一个或两个O、S或N杂原子的5元或6元取代或未取代的杂芳基或杂环基环，该环连接两个取代或未取代的6元芳基或杂芳基基团，这两个基团可以相同也可以不同。
• US3933840A
  申请人：——

  公开号：US3933840A

  公开（公告）日：1976-01-20
• US4051250A
  申请人：——

  公开号：US4051250A

  公开（公告）日：1977-09-27
• [EN] SELECTIVE COX-2 INHIBITORS<br/>[FR] INHIBITEURS SELECTIFS DE LA COX-2
  申请人：MICROBIA INC

  公开号：WO2005037227A2

  公开（公告）日：2005-04-28

  The invention features compounds that are inhibitors of COX-2 activity. Certain of the compounds are inhibitors of FAAH activity as well as COX-2 activity. The compounds include a 5-membered or 6-membered substituted or unsubstituted heteroaryl or heterocyclyl ring having one or two heteroatoms selected from the group consisting of O, S, and N that is linked to two substituted or unsubstituted 6-membered aryl or heteroaryl groups that can be the same or different.