α-Acetylmercapto-p-aminoacetophenon | 38773-45-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: α-Acetylmercapto-p-aminoacetophenon
• 英文别名: S-[2-(4-aminophenyl)-2-oxoethyl] ethanethioate
• CAS: 38773-45-4
• 化学式: C₁₀H₁₁NO₂S
• 分子量: 209.269
• InChiKey: DFCRFTYHWQDBFR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  85.5
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• [EN] NOVEL SULFONAMIDES AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE<br/>[FR] NOUVEAUX INHIBITEURS SULFONAMIDES DE HISTONE DECACETYLASE POUR LE TRAITEMENT DE MALADIES
  申请人：KALYPSYS INC

  公开号：WO2005120515A2

  公开（公告）日：2005-12-22

  Disclosed herein are carbonyl compounds of having the structural formula (I) or a pharmaceutically acceptable salt, amide, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
• [EN] MULTICYCLIC SULFONAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE<br/>[FR] COMPOSES SULFONAMIDE MULTICYCLIQUES INHIBANT L'HISTONE DESACETYLASE POUR LE TRAITEMENT DE MALADIE
  申请人：KALYPSYS INC

  公开号：WO2005123089A2

  公开（公告）日：2005-12-29

  Disclosed herein are carbonyl compounds of Formula (I) as described herein. Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
• [EN] INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE<br/>[FR] INHIBITEURS D'HISTONE DESACETYLASE POUR LE TRAITEMENT DE MALADIES
  申请人：KALYPSYS INC

  公开号：WO2007067993A1

  公开（公告）日：2007-06-14

  [EN] Disclosed herein are compounds of formula I and methods used for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine- repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
  [FR] La présente invention concerne des composés et des procédés utilisés pour traiter des états pathologiques comprenant, sans y être limités, des cancers, des maladies auto-immunes, des lésions tissulaires, des troubles du système nerveux central, des maladies neurodégénératives, la fibrose, des troubles osseux, des troubles de répétition de polyglutamine, des anémies, des thalassémies, des états inflammatoires, des troubles cardiovasculaires, et des troubles dans lesquels l'angiogenèse joue un rôle dans la pathogenèse. De plus, la présente invention concerne des procédés de modulation de l'activité de l'histone désacétylase (HDAC).
• [EN] INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE<br/>[FR] INHIBITEURS DE L'HISTONE DÉSACÉTYLASE POUR LE TRAITEMENT D'UNE MALADIE
  申请人：KALYPSYS INC

  公开号：WO2007067994A1

  公开（公告）日：2007-06-14

  [EN] Disclosed herein are carbonyl compounds of having the structural formula: (I) or a salt, ester, or prodrug thereof, Methods and compositions are disclosed for treating disease states including, but not limited to cancers, autoimmune diseases, tissue damage, central nervous system disorders, neurodegenerative disorders, fibrosis, bone disorders, polyglutamine-repeat disorders, anemias, thalassemias, inflammatory conditions, cardiovascular conditions, and disorders in which angiogenesis play a role in pathogenesis, using the compounds of the invention. In addition, methods of modulating the activity of histone deacetylase (HDAC) are also disclosed.
  [FR] L'invention concerne des composés carbonyle répondant à la formule structurelle : (I) ou un sel, ester ou promédicament de ceux-ci. L'invention concerne également des procédés et des compositions servant à traiter des maladies dont, mais sans y être limitées, des cancers, des maladies auto-immunes, un endommagement de tissu, des troubles du système nerveux central, des maladies neurodégénératives, une fibrose, des maladies des os, des maladies par expansion de polyglutamine, des anémies, des thalassémies, des affections inflammatoires, des affections cardiovasculaires et des troubles dans lesquels l'angiogenèse joue un rôle dans la pathogenèse, en utilisant les composés de l'invention. En plus, l'invention concerne des procédés de modulation de l'activité de l'histone désacétylase (HDAC).