tetraethylene glycol monophosphate | 145429-55-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tetraethylene glycol monophosphate
• 英文别名: 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl dihydrogen phosphate
• CAS: 145429-55-6
• 化学式: C₈H₁₉O₈P
• 分子量: 274.208
• InChiKey: IFYBJVSWSICROI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.7
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  tetraethylene glycol monophosphate 、 AMP-morpholidate 以 吡啶 为溶剂， 反应 48.0h， 生成 PEG-ADP
  参考文献：
  名称：

  Zou, Yekui; Yin, Jun, Journal of the American Chemical Society, 2009, vol. 131, p. 7548 - 7549

  摘要：

  DOI：

文献信息

• MMP-TARGETED THERAPEUTIC AND/OR DIAGNOSTIC NANOCARRIERS
  申请人：Mallinckrodt Inc.

  公开号：US20130183236A1

  公开（公告）日：2013-07-18

  The present invention provides targeted delivery compositions and methods of using the compositions for treating and diagnosing a disease state in a subject.

  本发明提供了针对性递送组合物以及使用这些组合物治疗和诊断受试者疾病状态的方法。
• Polyamide-oligonucleotide derivatives, their preparation and use
  申请人：Uhlmann Eugen

  公开号：US20050026817A1

  公开（公告）日：2005-02-03

  Polyamide-oligonucleotide derivatives of the formula F[(DNA-Li) q (PNA-Li) r (DNA-Li) s (PNA) t ] x F′ wherein q, r, s, t are, independently of one another, zero or 1, where the total of two or more adjacent q, r, s and t≧2; x is 1 to 20; DNA is a nucleic acid such as DNA or RNA or a known derivative thereof; Li is a covalent linkage between DNA and PNA, where the covalent linkage comprises a bond or an organic radical with at least one atom from the series consisting of C, N, O or S; PNA is a polyamide structure which contains at least one nucleotide base which is different from thymine; and F and F′ are end groups and/or are linked together by a covalent bond, and the physiologically tolerated salts thereof, a process for their preparation and their use as pharmaceutical, as gene probe and as primer, are described.

  本发明涉及一种多聚酰胺-寡核苷酸衍生物，其化学式为F[(DNA-Li)q(PNA-Li)r(DNA-Li)s(PNA)t]xF'，其中q、r、s、t独立地为0或1，相邻的两个或更多q、r、s和t的总和≧2；x为1到20；DNA是核酸，例如DNA或RNA或其已知衍生物；Li是DNA和PNA之间的共价连接，其中共价连接包括具有来自C、N、O或S系列中至少一个原子的键或有机基团；PNA是含有至少一个不同于胸腺嘧啶的核苷酸碱基的多聚酰胺结构；F和F'为末端基团和/或通过共价键连接在一起，以及其生理上可耐受的盐，描述了其制备过程以及作为制药、基因探针和引物的用途。
• Short oligonucleotides for the inhibition of VEGF expression
  申请人：Hoechst Marion Roussel Deutschland GmbH

  公开号：EP0979869A1

  公开（公告）日：2000-02-16

  The present invention relates to a short oligonucleotide or a derivative thereof which has a sequence that corresponds to a particular part of a nucleic acid sequence which encodes VEGF (vascular endothelial growth factor) and which has a length of maximum 15 nucleotides, the invention further relates to a method of making the oligonucleotide and the use thereof. A short oligonucleotide or a derivative thereof, which has a length of 10 to 15 nucleotides and which corresponds to a part of a VEGF encoding sequence, wherein the part of the VEGF encoding sequence to which the oligonucleotide corresponds to has one of the sequences SEQ ID NO. 1, SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4, SEQ ID NO. 5 or SEQ ID NO. 6 or a part thereof, wherein SEQ ID NO. 1 is   5'- CCCGGCCCCGGTCGGGCCTCCG - 3', SEQ ID NO. 2 is   5'- CGGGCCTCCGAAACC -3' , SEQ ID NO. 3 is   5'- GCTCTACCTCCACCATGCCAA -3', SEQ ID NO. 4 is   5'- GTGGTCCCAGGCTGCACCCATGGC -3', SEQ ID NO. 5 is   5'- CATCTTCAAGCCATCC -3', and SEQ ID NO. 6 is   5'- TGCGGGGGCTGCTGC -3'.

  本发明涉及一种短寡核苷酸或其衍生物，其序列对应于核酸序列的特定部分，该核酸序列编码VEGF（血管内皮生长因子），其长度不超过15个核苷酸，本发明还涉及一种制造该寡核苷酸的方法及其用途。 一种短寡核苷酸或其衍生物，其长度为 10 至 15 个核苷酸，与 VEGF 编码序列的一部分相对应，其中寡核苷酸所对应的 VEGF 编码序列的一部分具有 SEQ ID NO.1、SEQ ID NO.2、SEQ ID NO.3、SEQ ID NO.4、SEQ ID NO.5 或 SEQ ID NO.6 序列之一或其一部分、 其中 SEQ ID NO. 1 是 5'- CCCGGCCCCGGTCGGGCCTCCG - 3'、 SEQ ID NO. 2 是 5'- CGGGCCTCCGAAACC -3' 、 SEQ ID NO. 3 是 5'- GCTCTACCTCCACCATGCCAA -3'、 SEQ ID NO. 4 是 5'- GTGGTCCCAGGCTGCACCCATGGC -3'、 SEQ ID NO. 5 是 5'- CATCTTCAAGCCATCC -3', 和 SEQ ID NO. 6 是 5'- TGCGGGGGCTGCTGC -3'。
• Antisense oligonucleotides for the inhibition of VEGF expression
  申请人：Hoechst Marion Roussel Deutschland GmbH

  公开号：EP0978561A1

  公开（公告）日：2000-02-09

  The present invention relates to an oligonucleotide or a derivative thereof which has a sequence that corresponds to a part of a nucleic acid which encodes VEGF (vascular endothelial growth factor) and which has the ability to inhibit tumor growth in animal tumor models, the invention further relates to the preparation of such oligonucleotide and the use thereof. An oligonucleotide or a derivative thereof which has the sequence SEQ ID NO. 4 or a part thereof, wherein SEQ ID NO. 4 is 3'-GTACCTACAGATAGTCGCGTCGATGACGGTAGG-5, with the first proviso, that not all internucleoside bridges in the oligonucleotide are phosphodiester internucleoside bridges and not all phosphodiester internucleoside bridges are replaced by phosphorothioate internucleoside bridges and/or the second proviso, that the oligonucleotide contains no modified nucleosides selected from C5-propynyl uridine, C5-propynyl cytidine, C5-hexynyl uridine, C5-hexynyl cytidine, 6-aza uridine and 6-aza cytidine.

  本发明涉及一种寡核苷酸或其衍生物，其序列与编码血管内皮生长因子（VEGF）的核酸的一部分相对应，并且具有抑制动物肿瘤模型中肿瘤生长的能力，本发明进一步涉及这种寡核苷酸的制备及其用途。 一种寡核苷酸或其衍生物，其序列为 SEQ ID NO. SEQ ID NO. 4 是 3'-GTACCTACAGATAGTCGCGTCGATGACGGTAGG-5、 与 第一个但书，即寡核苷酸中并非所有的核苷酸间桥都是磷酸二酯核苷酸间桥，也并非所有的磷酸二酯核苷酸间桥都被硫代磷酸酯核苷酸间桥取代，和/或第二个但书、寡核苷酸不含有选自 C5-丙炔基尿苷、C5-丙炔基胞苷、C5-己炔基尿苷、C5-己炔基胞苷、6-氮杂尿苷和 6-氮杂胞苷的修饰核苷。
• C-class oligonucleotide analogs with enhanced immunostimulatory potency
  申请人：Coley Pharmaceutical GmbH

  公开号：EP1728863A2

  公开（公告）日：2006-12-06

  The invention relates to immunostimulatory oligonucleotides comprising the sequence TCGTCGTTTTACGGCGCCGTTGCCG (SEQ ID NO:44) and to their use in medicine, particularly in the treatment of cancer. The oligonucleotides are useful as adjuvants in vaccination. They are also useful for inducing an immune response and inducing type I interferon (IFN) expression.

  本发明涉及由序列 TCGTCGTTACGGCGCCGTTGCCG（SEQ ID NO:44）组成的免疫刺激寡核苷酸及其在医学中的用途，特别是在癌症治疗中的用途。寡核苷酸可用作疫苗接种的佐剂。它们还可用于诱导免疫反应和诱导 I 型干扰素 (IFN) 的表达。