| 1056652-08-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• CAS: 1056652-08-4
• 化学式: C₁₀H₁₄N₂O₆S₂
• 分子量: 322.363
• InChiKey: RMUCONGDXKDURK-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 sodium hydroxide 、 水 作用下， 以 四氢呋喃 为溶剂， 以100%的产率得到2-(3-Hydroxy-2-(2-(methylsulfonyl)acetamido)-2,3-dihydrothiazol-4-yl)acetic acid
  参考文献：
  名称：

  Discovery of novel hydroxy-thiazoles as HIF-α prolyl hydroxylase inhibitors: SAR, synthesis, and modeling evaluation

  摘要：

  Inhibition of the PHD2 enzyme has been associated with increased red blood cell levels. From a screening hit, a series of novel hydroxyl-thiazoles were developed as potent PHD2 inhibitors. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.06.031