申请人:Hattori Kazuo
公开号:US20090030195A1
公开(公告)日:2009-01-29
The present invention provides a compound having high antitumor activity, which is useful for therapeutic and preventive agents effective for proliferative diseases such as cancer; a production method thereof; an intermediate compound useful for such production; and a pharmaceutical composition comprising such a compound. The present invention provides a compound represented by the formula (1):
wherein X represents an aryl group or heteroaryl group which may be substituted, Cy represents a 4- to 7-membered monocyclic heterocyclic ring or a 8- to 10-membered condensed heterocyclic ring which may be substituted, and Z represents O, S, or NRa; or a prodrug thereof; or a pharmaceutically acceptable salt thereof; and a pharmaceutical and a pharmaceutical composition which comprise the compound.
本发明提供了一种具有高抗肿瘤活性的化合物,可用于治疗和预防增生性疾病如癌症的有效制剂;一种其生产方法;一种用于生产该化合物的中间体化合物;以及包含该化合物的药物组合物。本发明提供了一种由式(1)表示的化合物:其中X表示可能被取代的芳基团或杂环芳基团,Cy表示可能被取代的4-至7-成员单环杂环环或8-至10-成员的缩合杂环环,Z表示O,S或NRa;或其前药;或其药学上可接受的盐;以及包含该化合物的药物和药物组合物。