2-(dimethylamino)ethyl 2-((tert-butoxycarbonyl)amino)acetate | 43101-38-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(dimethylamino)ethyl 2-((tert-butoxycarbonyl)amino)acetate
• 英文别名: tert-Butoxycarbonylamino-acetic acid 2-dimethylamino-ethyl ester；Boc-glycine-2-(dimethylamino)ethyl ester；2-(dimethylamino)ethyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]acetate
• CAS: 43101-38-8
• 化学式: C₁₁H₂₂N₂O₄
• 分子量: 246.307
• InChiKey: DCBJORFCDSGZOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  溴氟甲烷 、 2-(dimethylamino)ethyl 2-((tert-butoxycarbonyl)amino)acetate 在 氢溴酸 作用下， 以 乙腈 为溶剂， 以23.1%的产率得到2-(2-aminoacetoxy)-N-(fluoromethyl)-N,N-dimethylethanaminium dibromide
  参考文献：
  名称：

  [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING PRODUCTION OF TRIMETHYLAMINE
  [FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS DE RÉDUCTION DE LA PRODUCTION DE TRIMÉTHYLAMINE

  摘要：

  Provided herein are substituted quaternary amine salt compounds and compositions thereof for inhibiting production of trimethylamine (TMA), as well as inhibiting the conversion of choline to trimethylamine, and such compounds, and compositions thereof, utilized for treating for example, kidney disease, diabetes and cardiovascular disease, disorders that are associated with inhibiting the conversion of choline to trimethylamine.

  公开号：

  WO2024011239A1
• 作为产物：
  描述：

  BOC-甘氨酸 、 N,N-二甲基乙醇胺 在 N,N'-羰基二咪唑 作用下， 以 四氢呋喃 为溶剂， 以9.7%的产率得到2-(dimethylamino)ethyl 2-((tert-butoxycarbonyl)amino)acetate
  参考文献：
  名称：

  [EN] COMPOUNDS, COMPOSITIONS, AND METHODS FOR REDUCING PRODUCTION OF TRIMETHYLAMINE
  [FR] COMPOSÉS, COMPOSITIONS ET PROCÉDÉS DE RÉDUCTION DE LA PRODUCTION DE TRIMÉTHYLAMINE

  摘要：

  Provided herein are substituted quaternary amine salt compounds and compositions thereof for inhibiting production of trimethylamine (TMA), as well as inhibiting the conversion of choline to trimethylamine, and such compounds, and compositions thereof, utilized for treating for example, kidney disease, diabetes and cardiovascular disease, disorders that are associated with inhibiting the conversion of choline to trimethylamine.

  公开号：

  WO2024011239A1

文献信息

• Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof
  申请人：Sheu Shey-Shing

  公开号：US20060160748A1

  公开（公告）日：2006-07-20

  Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

  本发明揭示了一种含有单个氨基酸、肽或其衍生物的化合物，该化合物可选择性地传递到细胞的线粒体。本发明的化合物表现出抗氧化活性，从而减少细胞内的反应性氧化物种。这些化合物对于抑制体内和体外氧化应激引起的细胞损伤或死亡非常有用。此外，本发明还揭示了这些化合物的合成方法。
• Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria and Use Thereof
  申请人：Sheu Shey-Shing

  公开号：US20090298782A1

  公开（公告）日：2009-12-03

  Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

  本发明揭示了包含单个氨基酸、多肽或其衍生物的化合物，这些化合物可选择性地传递到细胞的线粒体中。本发明的化合物表现出抗氧化活性，从而减少细胞中的反应性氧化物。这些化合物对于抑制体内和体外氧化应激诱导的细胞损伤或死亡非常有用。此外，还揭示了这些化合物的合成方法。
• Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria
  申请人：Sheu Shey-Shing

  公开号：US20110257107A1

  公开（公告）日：2011-10-20

  Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

  本发明涉及包含单个氨基酸、肽或其衍生物的化合物，这些化合物能够选择性地传递到细胞的线粒体。本发明的化合物表现出抗氧化活性，从而减少细胞内的反应性氧化物种。这些化合物对于抑制氧化应激诱导的细胞损伤或死亡在体内和体外均有用。此外，本发明还揭示了这些化合物的合成方法。
• COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF
  申请人：UNIVERSITY OF ROCHESTER

  公开号：EP1691818A2

  公开（公告）日：2006-08-23
• EP1691818A4
  申请人：——

  公开号：EP1691818A4

  公开（公告）日：2007-01-24