4-[cyano(3,3-difluorocyclobutyl)acetyl]benzonitrile | 1219019-03-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-[cyano(3,3-difluorocyclobutyl)acetyl]benzonitrile
• 英文别名: 4-[2-Cyano-2-(3,3-difluorocyclobutyl)acetyl]benzonitrile
• CAS: 1219019-03-0
• 化学式: C₁₄H₁₀F₂N₂O
• 分子量: 260.243
• InChiKey: WFLKKPIRPLLDII-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  64.6
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• [EN] AMIDE COMPOUNDS USEFUL IN THERAPY<br/>[FR] COMPOSÉS AMIDES UTILES EN THÉRAPIE
  申请人：PFIZER LTD

  公开号：WO2010032200A1

  公开（公告）日：2010-03-25

  A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, (I) wherein, R1 and R2 each independently represent H, halogen, CF3, C1-3 alkyl or C1-3 alkoxy; R3 represents C1-6 alkyl, C3-6 cycloalkyl, phenyl (optionally substituted by one or more substituents each independently selected from Ra) or Het (optionally substituted by one or more substituents each independently selected from OH, oxo, or C1-4 alkyl); R4 represents H or C1-3 alkyl; R5 represents C1-6 alkyl (optionally substituted by one or more substituents each independently selected from Rb), C3-6 cycloalkyl (optionally substituted by one or more substituents each independently selected from oxo or OH), or Het2 (optionally substituted by one or more substituents each independently selected from Rd); oxygen atom or 1 sulphur atom, or (c) 1 oxygen atom or 1 sulphur atom, (optionally substituted by one or more substituents each independently selected from OH, oxo or C1-4 alkyl); and R6 represents C1-3 alkyl (optionally substituted by one or more substituents each independently selected from Rf), C3-5 cycloalkyl (optionally substituted by one or more halogen), CN or halogen; where Rf represents halogen or phenyl: and compositions, processes for the preparation, and uses thereof, e.g. in the treatment of endometriosis or uterine fibroids.

  化合物的化学式（I），或其药学上可接受的盐或溶剂，其中，R1和R2分别独立表示H、卤素、CF3、C1-3烷基或C1-3烷氧基；R3表示C1-6烷基、C3-6环烷基、苯基（可选地由一个或多个Ra独立选择的取代基取代）或Het（可选地由一个或多个OH、氧代或C1-4烷基独立选择的取代基取代）；R4表示H或C1-3烷基；R5表示C1-6烷基（可选地由一个或多个Rb独立选择的取代基取代）、C3-6环烷基（可选地由一个或多个氧代或OH独立选择的取代基取代），或Het2（可选地由一个或多个Rd独立选择的取代基取代）；氧原子或1硫原子，或（c）1氧原子或1硫原子，（可选地由一个或多个OH、氧代或C1-4烷基独立选择的取代基取代）；和R6表示C1-3烷基（可选地由一个或多个Rf独立选择的取代基取代）、C3-5环烷基（可选地由一个或多个卤素取代）、CN或卤素；其中Rf表示卤素或苯基：以及其组合物、制备方法和用途，例如在子宫内膜异位症或子宫肌瘤的治疗中。
• Amide Compounds Useful in Therapy
  申请人：Gibson Karl Richard

  公开号：US20100249091A1

  公开（公告）日：2010-09-30

  A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein, R 1 and R 2 each independently represent H, halogen, CF 3 , C 1-3 alkyl or C 1-3 alkoxy; R 3 represents C 1-6 alkyl, C 3-6 cycloalkyl, phenyl (optionally substituted by one or more substituents each independently selected from R a ) or Het (optionally substituted by one or more substituents each independently selected from OH, oxo, or C 1-4 alkyl); R 4 represents H or C 1-3 alkyl; R 5 represents C 1-6 alkyl (optionally substituted by one or more substituents each independently selected from R b ), C 3-6 cycloalkyl (optionally substituted by one or more substituents each independently selected from oxo or OH), or Het 2 (optionally substituted by one or more substituents each independently selected from R d ); oxygen atom or 1 sulphur atom, or (c) 1 oxygen atom or 1 sulphur atom, (optionally substituted by one or more substituents each independently selected from OH, oxo or C 1-4 alkyl); and R 6 represents C 1-3 alkyl (optionally substituted by one or more substituents each independently selected from R f ), C 3-5 cycloalkyl (optionally substituted by one or more halogen), CN or halogen; where R f represents halogen or phenyl: and compositions, processes for the preparation, and uses thereof, e.g. in the treatment of endometriosis or uterine fibroids

  公式（I）的化合物，或其药学上可接受的盐或溶剂化物，其中，R1和R2各自独立地表示H、卤素、CF3、C1-3烷基或C1-3烷氧基；R3表示C1-6烷基、C3-6环烷基、苯基（可选择地由一个或多个取自Ra的取代基各自独立地取代）或Het（可选择地由一个或多个取自OH、氧代或C1-4烷基的取代基各自独立地取代）；R4表示H或C1-3烷基；R5表示C1-6烷基（可选择地由一个或多个取自Rb的取代基各自独立地取代）、C3-6环烷基（可选择地由一个或多个取自氧代或OH的取代基各自独立地取代）或Het2（可选择地由一个或多个取自Rd的取代基各自独立地取代）；氧原子或1个硫原子，或（c）1个氧原子或1个硫原子（可选择地由一个或多个取自OH、氧代或C1-4烷基的取代基各自独立地取代）；以及R6表示C1-3烷基（可选择地由一个或多个取自Rf的取代基各自独立地取代）、C3-5环烷基（可选择地由一个或多个卤素取代）CN或卤素；其中，Rf表示卤素或苯基：以及其制备的组合物、制备方法和用途，例如用于治疗子宫内膜异位症或子宫肌瘤。
• AMIDE COMPOUNDS USEFUL IN THERAPY
  申请人：GIBSON KARL RICHARD

  公开号：US20120316150A1

  公开（公告）日：2012-12-13

  A compound of Formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein, R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein: and compositions, processes for the preparation, and uses thereof, e.g. in the treatment of endometriosis or uterine fibroids.

  公式（I）的化合物，或其药学上可接受的盐或溶剂化物，其中，R1、R2、R3、R4、R5和R6如此定义：以及其制备的组合物、过程和用途，例如用于治疗子宫内膜异位症或子宫肌瘤。
• US8232269B2
  申请人：——

  公开号：US8232269B2

  公开（公告）日：2012-07-31