3,3-Bis-(4-hydroxyphenyl)-4-methylisatin | 94880-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 3,3-Bis-(4-hydroxyphenyl)-4-methylisatin
• CAS: 94880-97-4
• 化学式: C₂₁H₁₇NO₃
• 分子量: 331.371
• InChiKey: JDXZAORSJBQVQV-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  在 palladium on activated charcoal 氢气 、 potassium acetate 作用下， 以 甲醇 为溶剂， 以70%的产率得到3,3-Bis-(4-hydroxyphenyl)-4-methylisatin
  参考文献：
  名称：

  Syntheses and antiproliferative evaluation of oxyphenisatin derivatives

  摘要：

  Syntheses and structure-antiproliferative relationship for oxyphenisatin analogues are described. The cell proliferation data showed that the presence of substituents (especially F, Cl, Me, CF3, and OMe) in the 6- and 7-position of oxyphenisatin markedly enhanced the potency in the MDA-468 cell line without affecting the MDA-231 cell line. The best compounds from this series showed low nanomolar antiproliferative activity towards the MDA-468 cell line and a 1000-fold selectivity over the MDA-231 cell line. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.02.060