methyl 2-((2S,3R,4S)-3-(tert-butyldimethylsilyloxymethyl)-3,4-isopropylidene-dihydroxytetrahydrofuran-2-yl)acetate | 1025063-34-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2-((2S,3R,4S)-3-(tert-butyldimethylsilyloxymethyl)-3,4-isopropylidene-dihydroxytetrahydrofuran-2-yl)acetate
• CAS: 1025063-34-6
• 化学式: C₁₇H₃₂O₆Si
• 分子量: 360.523
• InChiKey: DKQFHQTYZSCQNQ-GDZNZVCISA-N

反应信息

• 作为产物：
  描述：

  (4S,5S,E)-methyl 4-(tert-butyldimethylsilyloxymethyl)-4,5-O-isopropylidene-4,5,6-trihydroxyhex-2-enoate 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 48.0h， 以70%的产率得到methyl 2-((2S,3R,4S)-3-(tert-butyldimethylsilyloxymethyl)-3,4-isopropylidene-dihydroxytetrahydrofuran-2-yl)acetate
  参考文献：
  名称：

  Facile synthesis of 6a-carba-β-d-fructopyranose through an RCM approach

  摘要：

  A new synthetic approach toward 6a-carba-beta-D-fructopyranose, a non-nutritive sweetener related to topiramate, is described. This scheme uses 2-C-hydroxymethyl-L-erythrose acetonide as starting material and efficiently delivers the target compound applying an RCM protocol for the construction of the carbocycle ring. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.02.046