5-chloro-3-(2-(4-fluorophenyl)-2-oxoethylidene)indolin-2-one | 173416-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5-chloro-3-(2-(4-fluorophenyl)-2-oxoethylidene)indolin-2-one
• CAS: 173416-93-8
• 化学式: C₁₆H₉ClFNO₂
• 分子量: 301.704
• InChiKey: IEDFTHAPMRMOFQ-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  5-chloro-3-(2-(4-fluorophenyl)-2-oxoethylidene)indolin-2-one 在 双氧水 、 十六烷基三甲基溴化铵 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 0.2h， 以90%的产率得到
  参考文献：
  名称：

  Facile stereoslective synthesis of spiro[indole-oxiranes] by combination of phase transfer catalyst and ultrasound irradiation and their bioassay

  摘要：

  An alternative and environmentally benign pathway for diastereoslective synthesis of fluorinated spiro[indole-3,2'-oxirane]-3'-benzoyl-2(1H)-ones (2a-g) is reported. The spiro[indole-3.2'-oxiranes] derivatives were obtained in 90-97% yield exclusively via the epoxidation of 3-aroylmethylene indole-2-ones with 30% aqueous hydrogen peroxide using cetyltrimethyl ammonium bromide as a phase transfer catalyst under ultrasound irradiation. The lead compounds have been tested for their antimicrobial activity and antioxidant properties. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ultsonch.2010.12.010

文献信息

• Substrate-controlled product-selectivity in the reaction of the Bestmann–Ohira reagent with N-unprotected isatin-derived olefins
  作者：Ashis Kumar Gupta、Shakir Ahamad、Ekta Gupta、Ruchir Kant、Kishor Mohanan

  DOI：10.1039/c5ob01382h

  日期：——

  A mild and efficient reaction of the Bestmann–Ohira reagent with N-unprotected isatin-derived olefins has been developed for the selective synthesis of spiro-pyrazoline-oxindoles and tricyclic pyrazoles. The reaction features an attractive product-selectivity depending on the substituent on isatin-derived olefin. Treatment of 3-aryl/alkylideneoxindoles with BOR afforded spiropyrazoline-oxindoles, whereas

  已开发出Bestmann–Ohira试剂与N-未保护的异麦芽酮素衍生的烯烃进行温和而有效的反应，以选择性合成螺-吡唑啉-吲哚和三环吡唑。该反应的特征在于诱人的产物选择性，这取决于衍生自直链烯烃的烯烃上的取代基。用BOR处理3-芳基/亚烷基新吲哚类化合物可得到螺并吡唑啉-吲哚类化合物，而3-苯并亚甲基新吲哚类化合物通过独特的扩环反应可提供吡唑并喹唑啉酮类化合物。