BIOCOMPATIBLE CROSSLINKED HYDROGELS, DRUG-LOADED HYDROGELS AND METHODS OF USING THE SAME
申请人:He Yuehua
公开号:US20090324720A1
公开(公告)日:2009-12-31
Disclosed are hydrogel compositions formed by the mixture of a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more electrophilic groups, and a tetramethylmethane substituted with one or more polyethylene glycols, and wherein each polyethylene glycol substituent is independently further substituted with one or more nucleophilic groups. Disclosed are also methods of preparing the above hydrogels. The hydrogel compositions can further comprise pharmaceuticals, such as analgesics or local anesthetics. Disclosed are also methods of sealing a wound, preventing post-surgical adhesion, and reducing post-surgical pain using the disclosed hydrogels.
本发明揭示了一种由四甲基甲烷与一种或多种聚乙二醇混合而成的水凝胶组合物,其中每个聚乙二醇取代基独立地进一步取代有一种或多种亲电基团,以及由一种或多种聚乙二醇取代基独立地进一步取代有一种或多种亲核基团的四甲基甲烷与一种或多种聚乙二醇混合而成的水凝胶组合物。本发明还揭示了制备上述水凝胶的方法。水凝胶组合物还可以包含药物,例如止痛药或局部麻醉剂。本发明还揭示了使用上述水凝胶密封伤口、预防术后粘连和减轻术后疼痛的方法。