(Z)-Hept-5-en-1-yn-3-ol | 90302-06-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (Z)-Hept-5-en-1-yn-3-ol
• CAS: 90302-06-0
• 化学式: C₇H₁₀O
• 分子量: 110.156
• InChiKey: MAIAJIOFZLUVCD-HYXAFXHYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  Trimethyl-[3-((S)-1-methyl-allyloxy)-prop-1-ynyl]-silane 在 正丁基锂 、 cesium fluoride 作用下， 生成 (Z)-Hept-5-en-1-yn-3-ol 、 (E)-(S)-Hept-5-en-1-yn-3-ol 、 (E)-(R)-Hept-5-en-1-yn-3-ol
  参考文献：
  名称：

  通过手性烯丙基炔丙基醚系统的 [2,3]-WITTIG 重排进行 1,4-手性转移。手性丙炔醇的一个新的、实用的入口

  摘要：

  对映体富集的 α-甲基烯丙基炔丙基醚的 [2,3]-Wittig 重排提供了高度（约 90%）的 1,4-手性转移，以​​及 95-98% 的 (E)-选择性。观察到的 1,4-手性转移的意义是在机械论基础上讨论的。

  DOI：

  10.1246/cl.1984.255

文献信息

• INHIBITORS OF D-AMINO ACID OXIDASE
  申请人：Heffernan Michele L. R.

  公开号：US20100029737A1

  公开（公告）日：2010-02-04

  The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein modulation of D-serine levels, and/or its oxidative products, is effective in ameliorating symptoms. The invention further provides methods of enhancing learning, memory and/or cognition. For example, the invention provides methods for treating or preventing loss of memory and/or cognition associated with neurodegenerative diseases, such as Alzheimer's disease. The invention further provides methods for preventing loss of neuronal function characteristic of neurodegenerative diseases. In addition, methods are provided for the treatment or prevention of neuropsychiatric diseases (e.g., schizophrenia) and for the treatment or prevention of pain and ataxia.

  本发明提供了新型D-氨基酸氧化酶酶的抑制剂。本发明的化合物可用于治疗或预防疾病和/或症状，其中调节D-丝氨酸水平和/或其氧化产物对缓解症状有效。本发明还提供了增强学习，记忆和/或认知的方法。例如，本发明提供了用于治疗或预防神经退行性疾病（如阿尔茨海默病）相关的记忆和/或认知丧失的方法。本发明还提供了预防神经退行性疾病特征性神经元功能丧失的方法。此外，还提供了用于治疗或预防神经精神疾病（例如，精神分裂症）和用于治疗或预防疼痛和共济失调的方法。
• US7902252B2
  申请人：——

  公开号：US7902252B2

  公开（公告）日：2011-03-08
• [EN] INHIBITORS OF D-AMINO ACID OXIDASE<br/>[FR] INHIBITEURS DE D-AMINO ACIDE OXYDASE
  申请人：SEPRACOR INC

  公开号：WO2011011330A2

  公开（公告）日：2011-01-27

  The present invention provides novel inhibitors of the enzyme D-amino acid oxidase. The compounds of the invention are useful for treating or preventing diseases and/or condition, wherein modulation of D-serine levels, and/or its oxidative products, is effective in ameliorating symptoms. The invention further provides methods of enhancing learning, memory and/or cognition. For example, the invention provides methods for treating or preventing loss of memory and/or cognition associated with neurodegenerative diseases, such as Alzheimer's disease. The invention further provides methods for preventing loss of neuronal function characteristic of neurodegenerative diseases. In addition, methods are provided for the treatment or prevention of neuropsychiatric diseases (e.g., schizophrenia) and for the treatment or prevention of pain and ataxia.
• 1,4-CHIRALITY TRANSFER VIA THE [2,3]-WITTIG REARRANGEMENT OF CHIRAL ALLYLIC PROPARGYL ETHER SYSTEM. A NEW, PRACTICAL ENTRY TO CHIRAL PROPARGYLIC ALCOHOLS
  作者：Noboru Sayo、Fumiyuki Shirai、Takeshi Nakai

  DOI：10.1246/cl.1984.255

  日期：1984.2.5

  The [2,3]-Wittig rearrangement of enantiomerically-enriched α-methylallyl propargyl ethers provides a high degree (ca. 90%) of 1,4-chirality transfer, together with 95–98% of (E)-selectivity. The observed sense of 1,4-chirality transfer is discussed on mechanistic grounds.

  对映体富集的 α-甲基烯丙基炔丙基醚的 [2,3]-Wittig 重排提供了高度（约 90%）的 1,4-手性转移，以​​及 95-98% 的 (E)-选择性。观察到的 1,4-手性转移的意义是在机械论基础上讨论的。