(2,4-Dimethoxy-5-pyrimidinyl)(2-ethyl-4,5-dimethoxyphenyl)methanone | 1145716-11-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2,4-Dimethoxy-5-pyrimidinyl)(2-ethyl-4,5-dimethoxyphenyl)methanone
• 英文别名: (2,4-dimethoxypyrimidin-5-yl)-(2-ethyl-4,5-dimethoxyphenyl)methanone
• CAS: 1145716-11-5
• 化学式: C₁₇H₂₀N₂O₅
• 分子量: 332.356
• InChiKey: XYVLJJWAILYSGZ-UHFFFAOYSA-N

物化性质

• 沸点：
  532.5±60.0 °C(Predicted)
• 密度：
  1.175±0.06 g/cm3(Predicted)

反应信息

• 作为反应物：
  描述：

  (2,4-Dimethoxy-5-pyrimidinyl)(2-ethyl-4,5-dimethoxyphenyl)methanone 在 氨 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X3/P2X2/3 antagonist for the treatment of pain

  摘要：

  P2X purinoceptors are ligand-gated ion channels whose endogenous ligand is ATP. Both the P2X(3) and P2X(2/3) receptor subtypes have been shown to play an important role in the regulation of sensory function and dual P2X(3)/P2X(2/3) antagonists offer significant potential for the treatment of pain. A high-throughput screen of the Roche compound collection resulted in the identification of a novel series of diaminopyrimidines; subsequent optimization resulted in the discovery of RO-4, a potent, selective and drug-like dual P2X(3)/P2X(2/3) antagonist. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.003
• 作为产物：
  描述：

  在 manganese(IV) oxide 作用下， 以 甲苯 为溶剂， 生成 (2,4-Dimethoxy-5-pyrimidinyl)(2-ethyl-4,5-dimethoxyphenyl)methanone
  参考文献：
  名称：

  Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X3/P2X2/3 antagonist for the treatment of pain

  摘要：

  P2X purinoceptors are ligand-gated ion channels whose endogenous ligand is ATP. Both the P2X(3) and P2X(2/3) receptor subtypes have been shown to play an important role in the regulation of sensory function and dual P2X(3)/P2X(2/3) antagonists offer significant potential for the treatment of pain. A high-throughput screen of the Roche compound collection resulted in the identification of a novel series of diaminopyrimidines; subsequent optimization resulted in the discovery of RO-4, a potent, selective and drug-like dual P2X(3)/P2X(2/3) antagonist. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.003