5-Ethyl-1H-pyrrole-3-carboxaldehyde | 78210-62-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5-Ethyl-1H-pyrrole-3-carboxaldehyde
• 英文别名: 5-ethyl-1H-pyrrole-3-carbaldehyde
• CAS: 78210-62-5
• 化学式: C₇H₉NO
• 分子量: 123.15
• InChiKey: WFORGMLGBPUZFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME
  申请人：Millennium Pharmaceuticals, Inc.

  公开号：EP3016934B1

  公开（公告）日：2018-01-10
• HETEROARYL INHIBITORS OF SUMO ACTIVATING ENZYME
  申请人：MILLENNIUM PHARMACEUTICALS, INC.

  公开号：US20160355504A1

  公开（公告）日：2016-12-08

  Disclosed are compounds of formula (I); or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra′, Rc, Rf, X2, Rd, Rd′, Re, Re′2, m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.
• US9695154B2
  申请人：——

  公开号：US9695154B2

  公开（公告）日：2017-07-04
• [EN] HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME<br/>[FR] COMPOSÉS HÉTÉROARYLIQUES POUVANT ÊTRE UTILISÉS EN TANT QU'INHIBITEURS DE L'ENZYME SAE
  申请人：MILLENNIUM PHARM INC

  公开号：WO2015002994A2

  公开（公告）日：2015-01-08

  Disclosed are compounds of formula (I): or a pharmaceutically acceptable salt thereof; wherein Y, Ra, Ra', Rc, Rf, X2, Rd, Rd', Re, Re', m, and G have the values described herein and stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry, useful as inhibitors of Sumo Activating Enzyme (SAE). Further provided are pharmaceutical compositions comprising a compound of the disclosure and methods of using the compositions in the treatment of proliferative, inflammatory, cardiovascular and neurodegenerative diseases or disorders.