(2S,4S,5S)-1-(tert-butoxycarbonyl)-4-(dimethylcarbamoyl)-5-methyl-2-pyrrolidinecarboxylic acid | 924308-18-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S,4S,5S)-1-(tert-butoxycarbonyl)-4-(dimethylcarbamoyl)-5-methyl-2-pyrrolidinecarboxylic acid
• 英文别名: (2S,4S,5S)-4-(dimethylcarbamoyl)-5-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
• CAS: 924308-18-9
• 化学式: C₁₄H₂₄N₂O₅
• 分子量: 300.355
• InChiKey: NGCOVOGJOINPEJ-GUBZILKMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  87.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2S,4S,5S)-1-(tert-butoxycarbonyl)-4-(dimethylcarbamoyl)-5-methyl-2-pyrrolidinecarboxylic acid 、 (乙基氨基)-乙腈 在 吡啶 、 三聚氟氰 作用下， 以 二氯甲烷 、 1,2-二氯乙烷 为溶剂， 反应 1.5h， 生成 tert-butyl (2S,3S,5S)-5-[(cyanomethyl)(ethyl)carbamoyl]-3-(dimethylcarbamoyl)-2-methyl-1-pyrrolidinecarboxylate
  参考文献：
  名称：

  Discovery of long-acting N-(cyanomethyl)-N-alkyl-l-prolinamide inhibitors of dipeptidyl peptidase IV

  摘要：

  Details of structure-activity relationships (SAR) for P2 moiety of a P1 2-cyanopyrrolidine dipeptidyl peptidase IV (DPP-IV) inhibitor 4a including stereochemistry are presented. Based on this information, a series of PI (N-alkyl)aminoacetonitrile analogs 9-20 possessing optimal P2 structure were synthesized and evaluated as inhibitors of DPP-IV. Among them, a representative compound 11, N-(cyanomethyl)-N-ethyl-L-prolinamide, was further evaluated to determine its effect on the plasma glucose level. Also 4a, 10, and 11 were evaluated for their isozyme selectivity to predict their safety problems. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.005
• 作为产物：
  描述：

  1-tert-butyl 2-methyl (2S,4S,5S)-4-(dimethylcarbamoyl)-5-methyl-1,2-pyrrolidinedicarboxylate 在 sodium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 23.0h， 以57%的产率得到(2S,4S,5S)-1-(tert-butoxycarbonyl)-4-(dimethylcarbamoyl)-5-methyl-2-pyrrolidinecarboxylic acid
  参考文献：
  名称：

  Discovery of long-acting N-(cyanomethyl)-N-alkyl-l-prolinamide inhibitors of dipeptidyl peptidase IV

  摘要：

  Details of structure-activity relationships (SAR) for P2 moiety of a P1 2-cyanopyrrolidine dipeptidyl peptidase IV (DPP-IV) inhibitor 4a including stereochemistry are presented. Based on this information, a series of PI (N-alkyl)aminoacetonitrile analogs 9-20 possessing optimal P2 structure were synthesized and evaluated as inhibitors of DPP-IV. Among them, a representative compound 11, N-(cyanomethyl)-N-ethyl-L-prolinamide, was further evaluated to determine its effect on the plasma glucose level. Also 4a, 10, and 11 were evaluated for their isozyme selectivity to predict their safety problems. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.005