2,2-Bis(prop-2-enoyloxymethyl)butyl 3-[2-[bis[3-[2,2-bis(prop-2-enoyloxymethyl)butoxy]-3-oxopropyl]amino]ethylamino]propanoate | 893412-11-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2-Bis(prop-2-enoyloxymethyl)butyl 3-[2-[bis[3-[2,2-bis(prop-2-enoyloxymethyl)butoxy]-3-oxopropyl]amino]ethylamino]propanoate
• CAS: 893412-11-8
• 化学式: C₄₇H₆₈N₂O₁₈
• 分子量: 949.06
• InChiKey: MZOCDOZGPCQGJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  67
• 可旋转键数：
  48
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  252
• 氢给体数：
  1
• 氢受体数：
  20

反应信息

• 作为反应物：
  描述：

  2,2-Bis(prop-2-enoyloxymethyl)butyl 3-[2-[bis[3-[2,2-bis(prop-2-enoyloxymethyl)butoxy]-3-oxopropyl]amino]ethylamino]propanoate 、 2-巯基乙醇 以 乙二醇二甲醚 为溶剂， 反应 48.0h， 生成
  参考文献：
  名称：

  [EN] DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY
  [FR] POLYMERES DENDRITIQUES AVEC FONCTIONNALITE INTERIEURE ET AMPLIFICATION RENFORCEES

  摘要：

  公开号：

  WO2006115547A3
• 作为产物：
  描述：

  乙二胺 、 三羟甲基丙烷三丙烯酸酯 以 甲醇 为溶剂， 反应 18.08h， 生成 2,2-Bis(prop-2-enoyloxymethyl)butyl 3-[2-[bis[3-[2,2-bis(prop-2-enoyloxymethyl)butoxy]-3-oxopropyl]amino]ethylamino]propanoate 、
  参考文献：
  名称：

  [EN] DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY
  [FR] POLYMERES DENDRITIQUES AVEC FONCTIONNALITE INTERIEURE ET AMPLIFICATION RENFORCEES

  摘要：

  公开号：

  WO2006115547A3

文献信息

• Unique steric and geometry induced stoichiometries observed in the divergent synthesis of poly(ester-acrylate/amine) (PEA) dendrimers
  作者：Douglas R. Swanson、Baohua Huang、Hosam G. Abdelhady、Donald A. Tomalia

  DOI：10.1039/b700193m

  日期：——

  controlled dendrimers possessing, macrocyclic (looped) structures (i.e., geometrically induced stoichiometry (GIS)) were formed when adequate reactivity space was available on the amine scaffolding. However, when amine core reaction sites became highly congested, one observed the formation of well defined, non-ideal dendrimers exhibiting sterically induced stoichiometries (SIS). It is postulated that

  这项工作描述了未保护的，支链的（A）x型丙烯酸酯单体（即，三羟甲基丙烷三丙烯酸酯（TMPTA）；x = 3或季戊四醇四丙烯酸酯（PTA）；X = 4），以温和的条件下的各种单和多亚烷基胺内核，以产生（芯：胺）; G = 1；[树状-聚（酯-丙烯酸酯）z ]；（PEA）型树状聚合物的一步。十分明显的是，这种策略并不需要像传统的Tomalia型聚（酰氨基胺）（PAMAM）树状大分子合成所需要的那样，需要大量过量的试剂方案，而产生的寡聚/聚合物副产物却相对较少。以高收率获得了理想的，数学上可预测的树枝状大分子结构，仅适度过量（即，4.0摩尔的单体/核心-NH）；而在较低的比率（即0.5 / 2.0摩尔的单体/核心-NH）下，具有几何结构的非理想树枝状大分子具有大环（环状）结构（即当胺骨架上有足够的反应空间时，就形成了几何诱导化学计量（GIS）。但是，当胺核心反​​应位变得高度拥挤时，人们观察到形
• Dendritic polymers with enhanced amplification and interior functionality
  申请人：Dendritic Nanotechnologies Inc.

  公开号：EP2325236A1

  公开（公告）日：2011-05-25

  Dendritic polymers of the macromolecular structure of Figur 1 are disclosed. The dendritic polymers have enhanced amplification and interior functionality. The dendritic polymers are made by use of fact, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled manner to rapidly and precisely build dendritic structures with cleaner chemistry and often with single products. Additional benefits include lower excesses of regents, lower levels of dilution, higher capacity, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The compositions prepared have novel internal functionality, including increased thermal stability and no reverse Michael's reaction, and reach encapsulation surface densities at lower generations.

  图 1 公开了大分子结构的树枝状聚合物。树枝状聚合物具有更强的放大和内部功能。树枝状聚合物是通过使用事实、反应性开环化学（或其他快速反应），结合使用分支细胞试剂，以受控的方式快速、精确地构建树枝状结构，化学反应更纯净，通常只有单一产物。其他优点还包括：调节剂用量更少、稀释程度更低、容量更大、更容易扩展到商业规模、材料范围更广、成本更低。所制备的组合物具有新颖的内部功能性，包括热稳定性更高，不会发生迈克尔反向反应，并能在较低世代达到封装表面密度。
• Dendritic Polymers With Enhanced Amplification and Interior Functionality
  申请人：Tomalia A. Donald

  公开号：US20070298006A1

  公开（公告）日：2007-12-27

  Dendritic polymers with enhanced amplification and interior functionality are disclosed. These dendritic polymers are made by use of fast, reactive ring-opening chemistry (or other fast reactions) combined with the use of branch cell reagents in a controlled way to rapidly and precisely build dendritic structures, generation by generation, with cleaner chemistry, often single products, lower excesses of reagents, lower levels of dilution, higher capacity method, more easily scaled to commercial dimensions, new ranges of materials, and lower cost. The dendritic compositions prepared have novel internal functionality, greater stability (e.g., thermal stability and less or no reverse Michael's reaction), and reach encapsulation surface densities at lower generations. Unexpectedly, these reactions of polyfunctional branch cell reagents with polyfunctional cores do not create cross-linked materials. Such dendritic polymers are useful as demulsifiers for oil/water emulsions, wet strength agents in the manufacture of paper, proton scavengers, polymers, nanoscale monomers, calibration standards for electron microscopy, making size selective membranes, and agents for modifying viscosity in aqueous formulations such as paint. When these dendritic polymers have a carried material associated with their surface and/or interior, then these dendritic polymers have additional properties for carrying materials due to the unique characteristics of the dendritic polymer, such as for drug delivery, transfection, and diagnostics.
• US7985424B2
  申请人：——

  公开号：US7985424B2

  公开（公告）日：2011-07-26
• [EN] DENDRITIC POLYMERS WITH ENHANCED AMPLIFICATION AND INTERIOR FUNCTIONALITY<br/>[FR] POLYMERES DENDRITIQUES AVEC FONCTIONNALITE INTERIEURE ET AMPLIFICATION RENFORCEES
  申请人：DENDRITIC NANOTECHNOLOGIES INC

  公开号：WO2006115547A3

  公开（公告）日：2009-06-04