4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-[3-(3-morpholin-4-yl-propionylamino)-phenoxy]-benzamide | 1226911-70-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-fluoro-2-(2-fluoro-4-iodo-phenylamino)-6-[3-(3-morpholin-4-yl-propionylamino)-phenoxy]-benzamide
• 英文别名: 4-Fluoro-2-(2-fluoro-4-iodoanilino)-6-[3-(3-morpholin-4-ylpropanoylamino)phenoxy]benzamide
• CAS: 1226911-70-1
• 化学式: C₂₆H₂₅F₂IN₄O₄
• 分子量: 622.41
• InChiKey: MFQMKXFEOHYHPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• SUBSTITUTED AMIDO PHENOXYBENZAMIDES
  申请人：Hartung Ingo

  公开号：US20110237592A1

  公开（公告）日：2011-09-29

  The present invention relates to substituted amido phenoxybenzamide compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the claims, to pharmaceutical compositions and combinations containing said compounds, to methods of preparing said compounds, and to the use of said compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.

  本发明涉及一般式（I）的取代氨基苯氧基苯酰胺化合物，其中A，R1，R2，R3，R4，R5，R6，R7，R8，R9和n如权利要求所定义，以及包含所述化合物的制药组合物和组合物，制备所述化合物的方法以及使用所述化合物或组合物治疗增生性和/或血管生成障碍的用途，作为单一制剂或与其他活性成分组合使用。
• [EN] SUBSTITUTED AMIDO PHENOXYBENZAMIDES<br/>[FR] AMIDO PHÉNOXYBENZAMIDES SUBSTITUÉS
  申请人：BAYER SCHERING PHARMA AG

  公开号：WO2010051935A2

  公开（公告）日：2010-05-14

  The present invention relates to substituted amido phenoxybenzamide compounds of general formula (I) in which A, R1, R2, R3, R4, R5, R6, R7, R8, R9 and n are as defined in the claims, to pharmaceutical compositions and combinations containing said compounds, to methods of preparing said compounds, and to the use of said compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.