8-chloro-5,6,6a,7,8,9,10,10a-octahydro-4-methyl-(3H)-benzo[c]quinolizin-3-one | 868829-97-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 8-chloro-5,6,6a,7,8,9,10,10a-octahydro-4-methyl-(3H)-benzo[c]quinolizin-3-one
• 英文别名: 8-Chloro-4-methyl-5,6,6a,7,8,9,10,10a-octahydrobenzo[f]quinolizin-3-one
• CAS: 868829-97-4
• 化学式: C₁₄H₁₈ClNO
• 分子量: 251.756
• InChiKey: BMBNOPUVLHQVRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Benzo (C)quinolizine derivatives, their preparation and use as 5-alphareductases inhibitors
  申请人：APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

  公开号：EP0926148A1

  公开（公告）日：1999-06-30

  The present invention refers to benzo[c]quinolizines derivatives, fully and partially saturated, having formula (I) and their pharmaceutically acceptable salts which proves useful for pharmaceutical and agricultural use being capable of inhibiting the 5α-reductase enzyme either selectively in respect of 5αR-I and 5αR-II or on both the iso-enzymes. Compounds (1) can be used to regulate growth and act as herbicides, or to treat acne, baldness, prostatic cancer and prostatic hypertrophy.

  本发明涉及苯并[c]喹啉衍生物，完全和部分饱和，其具有公式（I）及其药学上可接受的盐，对医药和农业用途有用，能够选择性地抑制5α-还原酶酶，无论是对于5αR-I和5αR-II还是对于两种亚型的酶。化合物（1）可用于调节生长并作为除草剂，或用于治疗痤疮，脱发，前列腺癌和前列腺肥大。
• Polyurethane coating cure enhancement using zirconium carbonate
  申请人：Li Minyu

  公开号：US20050153141A1

  公开（公告）日：2005-07-14

  Zirconiun carbonates can initiate hardening of polyurethane coatings and decrease the coating tack-free time. The decreased tack-free times facilitate earlier application of additional polyurethane layers and earlier return of a coated article to service, and can provide improved floor finishes.

  碳酸锆可使聚氨酯涂层开始硬化，并缩短涂层的无粘性时间。无粘性时间的缩短有利于更早地涂抹额外的聚氨酯涂层，更早地使涂过涂层的物品恢复使用，并可改善地板的光洁度。
• BENZO C]QUINOLIZINE DERIVATIVES AND THEIR USE AS 5 ALPHA-REDUCTASES INHIBITORS
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1066284A1

  公开（公告）日：2001-01-10
• BENZO(C)QUINOLIZINE DERIVATIVES AND THEIR USE AS 5 ALPHA-REDUCTASES INHIBITORS
  申请人：Applied Research Systems ARS Holding N.V.

  公开号：EP1066284B1

  公开（公告）日：2005-08-31
• JPH09141679A
  申请人：——

  公开号：JPH09141679A

  公开（公告）日：1997-06-03