7-(2''-bromobenzyl)-3-(2'-bromophenyl)-2-methyl-4,5,6,7-tetrahydro-2H-indazole | 1070967-33-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 7-(2''-bromobenzyl)-3-(2'-bromophenyl)-2-methyl-4,5,6,7-tetrahydro-2H-indazole
• CAS: 1070967-33-7
• 化学式: C₂₁H₂₀Br₂N₂
• 分子量: 460.211
• InChiKey: KTIKSTXRTWUVKJ-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  7-(2'-bromobenzylidene)-3-(2'-bromophenyl)-2-methyl-3,3a,4,5,6,7-hexahydro-2H-indazole 在 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以96%的产率得到7-(2''-bromobenzyl)-3-(2'-bromophenyl)-2-methyl-4,5,6,7-tetrahydro-2H-indazole
  参考文献：
  名称：

  The synthesis of highly functionalised pyridines using Ghosez-type reactions of dihydropyrazoles

  摘要：

  The aza-Diels-Alder reaction of alpha beta-unsaturated hydrazones is a general methodology that has been applied both to the synthesis of natural products and to the development of multicomponent reactions. Trends have emerged as to the effect of substituents on the efficiency of this reaction with substituents at the C2 and C4-positions of the aza-diene in general suppressing the reaction. Here we report that 4,5-dihydropyrazoles can function as substrates in this process despite the presence of substituents at both of these positions. A one pot, four chemical step sequence carried out under standard thermal or microwave conditions results in the formation of the corresponding pyridine-containing compounds. The scope of the reaction is explored and additional insights into the proposed mechanism of this reaction are provided. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.07.063