2-[2-(2-Hydroxyacetyl)oxypropanoyloxy]acetic acid | 1030930-20-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 肽模拟物
• 英文名称: 2-[2-(2-Hydroxyacetyl)oxypropanoyloxy]acetic acid
• CAS: 1030930-20-1
• 化学式: C₇H₁₀O₇
• 分子量: 206.152
• InChiKey: UNYAEVLMDHEEIR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  在 palladium 10% on activated carbon 、 氢气 作用下， 以 乙酸乙酯 为溶剂， 以100%的产率得到2-[2-(2-Hydroxyacetyl)oxypropanoyloxy]acetic acid
  参考文献：
  名称：

  New Insights into Poly(lactic-co-glycolic acid) Microstructure: Using Repeating Sequence Copolymers To Decipher Complex NMR and Thermal Behavior

  摘要：

  Sequence, which Nature uses to spectacular advantage, has not been fully exploited in synthetic copolymers. To investigate the effect of sequence and stereosequence on the physical properties of copolymers, a family of complex isotactic, syndiotactic, and atactic repeating sequence poly(lactic-co-glycolic acid) copolymers (RSC PLGAs) were prepared and their NMR and thermal behavior was studied. The unique suitability of polymers prepared from the bioassimilable lactic and glycolic acid monomers for biomedical applications makes them ideal candidates for this type of sequence engineering. Polymers with repeating units of LG, GLG and LLG (L = lactic, G = glycolic) with controlled and varied tacticities were synthesized by assembly of sequence-specific, stereopure dimeric, trimeric, and hexameric segmer units. Specifically labeled deuterated lactic and glycolic acid segmers were likewise prepared and polymerized. Molecular weights for the copolymers were in the range M-n = 12-40 kDa by size exclusion chromatography in THF. Although the effects of sequence-influenced solution conformation were visible in all resonances of the H-1 and C-13 NMR spectra, the diastereotopic methylene resonances in the H-1 NMR (CDCl3) for the glycolic units of the copolymers proved most sensitive. An octad level of resolution, which corresponds to an astounding 31-atom distance between the most separated stereocenters, was observed in some mixed sequence polymers. Importantly, the level of sensitivity of a particular NMR resonance to small differences in sequence was found to depend on the sequence itself. Thermal properties were also correlated with sequence.

  DOI：

  10.1021/ja102670n

文献信息

• ANTIMICROBIAL POLYMER COMPOSITIONS AND THE USE THEREOF
  申请人：ERNETA Modesto

  公开号：US20090092648A1

  公开（公告）日：2009-04-09

  An antimicrobial composition. The antimicrobial composition includes a complex of an anionic polyester with a monomeric amidoamine a complex of an anionic polyester with a monomeric amidoamine or an organic cation, wherein the monomeric amidoamine comprises: (R 1,2 )N—R 3 —NH—CO—R 4 wherein: R 1 ═H, Alkyl, Aryl, HO—(CH 2 CH 2 —O—) n —, MeO—(CH 2 CH 2 —O—) n —, HO—(CH 2 ) n —; R 2 ═H, Alkyl, Aryl, HO—(CH 2 CH 2 —O—) n —, MeO—(CH 2 CH 2 —O—) n —, HO—(CH 2 ) n —; R 3 =Alkyl, Aryl, —(CH 2 CH 2 —O—)—(CH 2 —) n ; R 4 =Alkyl, Aryl, —(CH 2 CH 2 —O—)—(CH 2 —) n —CH 3 , —O—CH 3 , —O—C 2 H 5 , —O—C 3 H 7 ; and n=1-30; and wherein the organic cation comprises: wherein: R 1 ═H, Alkyl, Aryl, HO—(CH 2 CH2-O—)n-, MeO—(CH2CH2-O—)n-, HO—(CH 2 )n-; R 2 ═H, Alkyl, Aryl, HO—(CH 2 CH2-O—)n-, MeO—(CH2CH2-O—)n, HO—(CH 2 )n-; R 3 ═H, Alkyl, Aryl, —(CH 2 CH 2 —O—)—(CH 2 —)n; R 4,5 ═H, Alkyl, Aryl, —(CH 2 CH 2 —O—)—(CH 2 -)n-CH 3 , —O—CH 3 , —O—C 2 H 5 , —O—C 3 H 7 ; and n=1-30; and the anionic polyester is selected from the group consisting of an anionic polyester having at least one carboxylic group, a sulfonic acid polymer, and a phosphoric acid polymer. A medical device having an antimicrobial composition that includes a complex of an anionic polyester with a monomeric amidoamine having at least one amide group and at least one amine group, wherein the amine group is either a primary amine, or a secondary amine, or a tertiary amine, or a quaternary amine, or a combination thereof and the anionic polyester has at least one carboxylic group is also provided.

  一种抗微生物组合物。该抗微生物组合物包括阴离子聚酯与单体酰胺胺的复合物，其中单体酰胺胺包括：(R1,2)N—R3—NH—CO—R4其中：R1═H，烷基，芳基，HO—( —O—)n—，MeO—( —O—)n—，HO—(CH2)n—；R2═H，烷基，芳基，HO—( —O—)n—，MeO—( —O—)n—，HO—( )n—；R3=烷基，芳基，—( —O—)—( —)n；R4=烷基，芳基，—( —O—)—( —)n—CH3，—O— ，—O—C2H5，—O—C3H7；n=1-30；有机阳离子包括：其中：R1═H，烷基，芳基，HO—( -O—)n-，MeO—( -O—)n-，HO—( )n-；R2═H，烷基，芳基，HO—( -O—)n-，MeO—( -O—)n，HO—( )n-；R3═H，烷基，芳基，—( —O—)—( —)n；R4,5═H，烷基，芳基，—( —O—)—( -)n- ，—O— ，—O— ，—O— ；n=1-30；阴离子聚酯选自包括至少一个羧基的阴离子聚酯、磺酸聚合物和磷酸聚合物的组。还提供了一种具有抗微生物组合物的医疗器械，该组合物包括阴离子聚酯与至少一个酰胺基团和至少一个胺基的单体酰胺胺的复合物，其中胺基是一次胺基、二次胺基、三次胺基、季胺基或其组合，且阴离子聚酯具有至少一个羧基。
• Transdermal delivery systems comprising bupivacaine
  申请人：Durect Corporation

  公开号：EP2484347A1

  公开（公告）日：2012-08-08

  Disclosed are bupivacaine transdermal delivery systems, and related methods.

  所公开的是布比卡因透皮给药系统及相关方法。
• TRANSDERMAL DELIVERY SYSTEMS COMPRISING BUPIVACAINE
  申请人：Durect Corporation

  公开号：EP2117521B1

  公开（公告）日：2012-06-27
• Antimicrobial polymer compositions and the use thereof.
  申请人：Ethicon, Inc.

  公开号：EP2401913B1

  公开（公告）日：2017-04-05
• Transdermal delivery systems
  申请人：Yum Su II

  公开号：US20090060986A1

  公开（公告）日：2009-03-05

  Disclosed are bupivacaine transdermal delivery systems, and related methods.