epi-5-N[(arginyl)aminoethyl]neamine | 1159108-10-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: epi-5-N[(arginyl)aminoethyl]neamine
• 英文别名: Nea-Eda-Arg；NEA
• CAS: 1159108-10-7
• 化学式: C₂₀H₄₄N₁₀O₆
• 分子量: 520.633
• InChiKey: YNWWXFGEJXGBNN-WUQJHABKSA-N

物化性质

• 密度：
  1.79±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

反应信息

• 作为反应物：
  描述：

  epi-5-N[(arginyl)aminoethyl]neamine 、 三氟乙酸 以 水 为溶剂， 以13 mg的产率得到
  参考文献：
  名称：

  Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA

  摘要：

  Three new derivatives of neamine, 3 (NE), 6 (NEA) and 9 (NEL), were synthesized by connecting arginine or lysine to 5-hydroxyl group of neamine using ethylenediamine as a linker. The binding affinities of these derivatives to A site of 16S RNA and TAR RNA indicate that the modi. cation on 5-hydroxyl of neamine by amino acid can enhance the binding affinity of neamine. Compound 9 (NEL) shows some antibacterial activities. These results demonstrate that modi. cation on 5-hydroxyl group of neamine may provide a promising way for the development of potential candidates effectively targeting to RNAs. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.021
• 作为产物：
  描述：

  在 吡啶 、 硫化氢 、 三乙胺 作用下， 以 水 为溶剂， 反应 1.0h， 生成 epi-5-N[(arginyl)aminoethyl]neamine
  参考文献：
  名称：

  Synthesis and evaluation of novel neamine derivatives effectively targeting to RNA

  摘要：

  Three new derivatives of neamine, 3 (NE), 6 (NEA) and 9 (NEL), were synthesized by connecting arginine or lysine to 5-hydroxyl group of neamine using ethylenediamine as a linker. The binding affinities of these derivatives to A site of 16S RNA and TAR RNA indicate that the modi. cation on 5-hydroxyl of neamine by amino acid can enhance the binding affinity of neamine. Compound 9 (NEL) shows some antibacterial activities. These results demonstrate that modi. cation on 5-hydroxyl group of neamine may provide a promising way for the development of potential candidates effectively targeting to RNAs. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.021