(2R,2'R)-neopentyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate | 1371541-70-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: (2R,2'R)-neopentyl 2,2'-((((2R,3R,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)phosphoryl)bis(azanediyl)dipropanoate
• 英文别名: 2,2-dimethylpropyl (2R)-2-[[[(2R,3R,4R,5R)-5-(2-amino-6-ethoxy-purin-9-yl)-4-fluoro-3-hydroxy-4-methyl-tetrahydrofuran-2-yl]methoxy-[[(1R)-2-(2,2-dimethylpropoxy)-1-methyl-2-oxo-ethyl]amino]phosphoryl]amino]propanoate；2,2-dimethylpropyl (2R)-2-[[[(2R,3R,4R,5R)-5-(2-amino-6-ethoxypurin-9-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-[[(2R)-1-(2,2-dimethylpropoxy)-1-oxopropan-2-yl]amino]phosphoryl]amino]propanoate
• CAS: 1371541-70-6
• 化学式: C₂₉H₄₉FN₇O₉P
• 分子量: 689.722
• InChiKey: SEPFVVMUCNBETD-PPFORKMISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  47
• 可旋转键数：
  18
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.76
• 拓扑面积：
  211
• 氢给体数：
  4
• 氢受体数：
  16

文献信息

• [EN] PHOSPHORODIAMIDATE DERIVATIVES OF GUANOSINE NUCLEOSIDE COMPOUNDS FOR TREATMENT OF VIRAL INJECTIONS<br/>[FR] DÉRIVÉS PHOSPHORODIAMIDATE DE COMPOSÉS NUCLÉOSIDIQUES À BASE DE GUANOSINE DESTINÉS À TRAITER DES INFECTIONS VIRALES
  申请人：INHIBITEX INC

  公开号：WO2012048013A2

  公开（公告）日：2012-04-12

  This invention is directed to novel compounds of formula (I) having the structure that are useful in the treatment of viral infections in mammals mediated, at least in part, by a virus in the Flaviviridae family of viruses. Methods of treating viral infections via administration of these compounds are also disclosed.