(R)-2-(1-cyclohexyloxyethoxy)-1-propanol | 342381-26-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-2-(1-cyclohexyloxyethoxy)-1-propanol
• 英文别名: (R)-(-)-2-(1-Cyclohexyloxyethoxy)-1-propanol；(2R)-2-(1-cyclohexyloxyethoxy)propan-1-ol
• CAS: 342381-26-4
• 化学式: C₁₁H₂₂O₃
• 分子量: 202.294
• InChiKey: SLXDUBWUJYUKLZ-YHMJZVADSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  isobutyl (R)-2-(1-cyclohexyloxyethoxy)propionate 在 sodium borohydrid 作用下， 以 甲醇 、 水 、 甲苯 为溶剂， 以88.7%的产率得到(R)-2-(1-cyclohexyloxyethoxy)-1-propanol
  参考文献：
  名称：

  EP1146032

  摘要：

  公开号：

文献信息

• Process for the production of alkanediol derivative
  申请人：Ihara Chemical Industry Co., Ltd.

  公开号：US06720463B1

  公开（公告）日：2004-04-13

  The present invention provides a process for producing an alkanediol derivative represented by the general formula (II) from an ester compound represented by the general formula (I), safely without giving rise to racemization. The present invention lies in a process for producing an alcohol derivative represented by the following general formula (II): (wherein R2 and R3 are each independently a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; X is a hydrogen atom or a protecting group for hydroxyl group; and n is 0 or 1), which process comprises reducing an ester compound represented by the following general formula (I): (wherein R1 is an alkyl group having 1 to 4 carbon atoms; and R2, R3, X and n have the same definitions as given above) with sodium borohydride in a mixed solvent of at least one kind of solvent selected from the group consisting of aromatic hydrocarbons, aliphatic hydrocarbons and alicyclic hydrocarbons and a primary alcohol.

  本发明提供了一种从代表通式（I）的酯化合物中安全地生产代表通式（II）的烷二醇衍生物的方法，而不产生旋光异构体。本发明涉及一种生产代表以下通式（II）的醇衍生物的方法：（其中R2和R3各自独立地为氢原子或具有1至4个碳原子的烷基；X为氢原子或羟基的保护基；n为0或1），该方法包括在至少一种溶剂的混合溶剂中，所述溶剂从芳香族烃、脂肪族烃和脂环烃组成的群体中选择至少一种溶剂和一种一级醇的存在下，用硼氢化钠还原代表以下通式（I）的酯化合物：（其中R1为具有1至4个碳原子的烷基；R2、R3、X和n具有上述相同的定义）。
• PROCESS FOR THE PRODUCTION OF ALKANEDIOL DERIVATIVES
  申请人：IHARA CHEMICAL INDUSTRY CO., LTD.

  公开号：EP1146032A1

  公开（公告）日：2001-10-17

  The present invention provides a process for producing an alkanediol derivative represented by the general formula (II) from an ester compound represented by the general formula (I), safely without giving rise to racemization. The present invention lies in a process for producing an alcohol derivative represented by the following general formula (II): (wherein R2 and R3 are each independently a hydrogen atom or an alkyl group having 1 to 4 carbon atoms; X is a hydrogen atom or a protecting group for hydroxyl group; and n is 0 or 1), which process comprises reducing an ester compound represented by the following general formula (I): (wherein R1 is an alkyl group having 1 to 4 carbon atoms; and R2, R3, X and n have the same definitions as given above) with sodium borohydride in a mixed solvent of at least one kind of solvent selected from the group consisting of aromatic hydrocarbons, aliphatic hydrocarbons and alicyclic hydrocarbons and a primary alcohol.

  本发明提供了一种从通式(I)所代表的酯类化合物生产通式(II)所代表的烷二醇衍生物的工艺，该工艺安全而不会引起消旋化。 本发明在于一种生产由以下通式（II）代表的醇衍生物的工艺： (其中 R2 和 R3 各自独立地为氢原子或具有 1 至 4 个碳原子的烷基；X 为氢原子或羟基的保护基团；n 为 0 或 1），该工艺包括还原由以下通式（I）代表的酯化合物： (其中 R1 是具有 1 至 4 个碳原子的烷基；R2、R3、X 和 n 的定义与上述相同）与硼氢化钠在至少一种选自芳香烃、脂肪烃、脂环烃和伯醇的混合溶剂中进行还原。
• US6720463B1
  申请人：——

  公开号：US6720463B1

  公开（公告）日：2004-04-13