(6,6,8,8-Tetraisopropyl-10H-5,7,9-trioxa-6,8-disila-benzocycloocten-2-yl)-methanol | 884324-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: (6,6,8,8-Tetraisopropyl-10H-5,7,9-trioxa-6,8-disila-benzocycloocten-2-yl)-methanol
• CAS: 884324-37-2
• 化学式: C₂₀H₃₆O₄Si₂
• 分子量: 396.674
• InChiKey: CTRAQDGRRVIXOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.63
• 重原子数：
  26.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  47.92
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (6,6,8,8-Tetraisopropyl-10H-5,7,9-trioxa-6,8-disila-benzocycloocten-2-yl)-methanol 在 吡啶 、 氯化亚砜 、 sodium azide 、 四丁基氟化铵 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 反应 7.17h， 生成 Pentanedioic acid mono-{2-azidomethyl-4-[(4-methoxy-phenyl)-diphenyl-methoxymethyl]-phenyl} ester
  参考文献：
  名称：

  A novel linker for solid-phase synthesis cleavable under neutral conditions

  摘要：

  A novel linker cleavable under neutral conditions has been developed for the solid-phase synthesis of base-labile compounds. The linker is comprised of a 3-azidomethyl-4-hydroxybenzyl alcohol moiety, and the azidomethyl group in the linker is readily converted to an aminomethyl group by treatment with a phosphine reagent in the presence of water to result in an intramolecular cyclization to release the compounds. Using the linker, a base-labile dinucleoside methyl phosphate was synthesized on a highly cross-linked polystyrene (HCP) support and cleaved successfully from the resin without decomposition of the product. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.01.135
• 作为产物：
  描述：

  1,3二氯-1,1,3,3-四异丙基二硅氧烷 、 间二甲苯-4,alpha,alpha'-三醇 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 以94%的产率得到(6,6,8,8-Tetraisopropyl-10H-5,7,9-trioxa-6,8-disila-benzocycloocten-2-yl)-methanol
  参考文献：
  名称：

  A novel linker for solid-phase synthesis cleavable under neutral conditions

  摘要：

  A novel linker cleavable under neutral conditions has been developed for the solid-phase synthesis of base-labile compounds. The linker is comprised of a 3-azidomethyl-4-hydroxybenzyl alcohol moiety, and the azidomethyl group in the linker is readily converted to an aminomethyl group by treatment with a phosphine reagent in the presence of water to result in an intramolecular cyclization to release the compounds. Using the linker, a base-labile dinucleoside methyl phosphate was synthesized on a highly cross-linked polystyrene (HCP) support and cleaved successfully from the resin without decomposition of the product. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.01.135