1-deoxy-1-(methylamino)-D-galactitol | 540470-49-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-deoxy-1-(methylamino)-D-galactitol
• 英文别名: 6-deoxy-6-(methylamino)-D-galactitol；(2S,3R,4S,5R)-6-(methylamino)hexane-1,2,3,4,5-pentol
• CAS: 540470-49-3
• 化学式: C₇H₁₇NO₅
• 分子量: 195.216
• InChiKey: MBBZMMPHUWSWHV-JRTVQGFMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  113
• 氢给体数：
  6
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-deoxy-1-(methylamino)-D-galactitol 、 在 N,N-二异丙基乙胺 作用下， 以 水 、 乙腈 为溶剂， 反应 5.0h， 生成 (2S,3R,4S,5R)-6-({4-(4-Methoxy-phenylamino)-6-[2-(4-methoxy-phenyl)-ethylamino]-[1,3,5]triazin-2-yl}-methyl-amino)-hexane-1,2,3,4,5-pentaol
  参考文献：
  名称：

  Incorporation of carbohydrates and peptides into large triazine-based screening libraries using automated parallel synthesis

  摘要：

  A procedure for the sequential, selective derivatization of cyanuric chloride that allows for the incorporation of carbohydrates and peptides has been elucidated. As a result, large combinatorial arrays of individual derivatives, over 40,000 in all, have been produced in 50 mu mole quantities using automated parallel solution phase synthesis. The use of this technology in a search for protease inhibitors, glycopeptide surrogates and other bioactive compound classes will also be discussed. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00134-3