2-{6-amino-5-(2-methoxyphenoxy)-2-morpholinopyrimidin-4-yloxy}ethanol | 184779-22-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-{6-amino-5-(2-methoxyphenoxy)-2-morpholinopyrimidin-4-yloxy}ethanol
• 英文别名: 2-[6-Amino-5-(2-methoxyphenoxy)-2-morpholin-4-ylpyrimidin-4-yl]oxyethanol
• CAS: 184779-22-4
• 化学式: C₁₇H₂₂N₄O₅
• 分子量: 362.385
• InChiKey: HRRHOIXWLGLPJZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• Arylalkane-sulfonamides having endothelin-antagonist activity
  申请人：——

  公开号：US20040102464A1

  公开（公告）日：2004-05-27

  The invention relates to novel aryl-alkane-sulfonamides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.

  这项发明涉及新型芳基-烷基-磺酰胺及其在制备药物组合物中作为活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有其中一种或多种化合物的药物组合物，特别是它们作为内皮素受体拮抗剂的用途。
• Novel sulfamides and their use as endothelin receptor antagonists
  申请人：——

  公开号：US20040077670A1

  公开（公告）日：2004-04-22

  The invention relates to novel sulfamides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.

  本发明涉及新型磺酰胺及其在制备药物组合物中作为活性成分的应用。该发明还涉及相关方面，包括化合物的制备过程、含有其中一种或多种化合物的药物组合物，以及它们作为内皮素受体拮抗剂的应用。
• [EN] NOVEL SULFAMIDES AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS<br/>[FR] NOUVEAUX SULFAMIDES ET LEUR UTILISATION COMME ANTAGONISTES DU RECEPTEUR DE L'ENDOTHELINE
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2002053557A1

  公开（公告）日：2002-07-11

  The invention relates to novel sulfamides of general formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.

  本发明涉及一种新型一般式（I）的磺胺类化合物，以及它们在制备药物组合物的活性成分中的应用。本发明还涉及相关方面，包括化合物的制备过程，含有其中一种或多种化合物的药物组合物，特别是它们作为内皮素受体拮抗剂的用途。
• Novel sulfamides
  申请人：Bolli Martin

  公开号：US20060178365A1

  公开（公告）日：2006-08-10

  The invention relates to novel sulfamides and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as endothelin receptor antagonists.

  本发明涉及新型磺酰胺及其在制备药物组合物中作为活性成分的用途。本发明还涉及相关方面，包括合成这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，特别是它们作为内皮素受体拮抗剂的用途。
• Sulfonamide derivative and process for preparing the same
  申请人：TANABE SEIYAKU CO., LTD.

  公开号：EP0743307A1

  公开（公告）日：1996-11-20

  Novel sulfonamide derivatives of the formula [I]: wherein Ring A and Ring B are substituted or unsubstituted monocyclic, bicyclic or tricyclic hydrocarbon, or substituted or unsubstituted heterocyclic group, Q is single bond, ―O―, ―S―, ―SO―, ―SO2― or ―CH2―, Y is ―O―, ―S― or ―NH―, Alk is lower alkylene or alkenylene, Z is ―O― or ―NH―, R is substituted or unsubstituted aromatic heterocyclic or aryl, R1 is H, trifluoromethyl, substituted or unsubstituted amino, substituted or unsubstituted lower alkyl, alkenyl, alkynyl, substituted or unsubstituted lower alkylthio, or alkoxy, or substituted or unsubstituted heterocyclic or aryl, or pharmaceutically acceptable salts thereof, which are useful in the prophylaxis or treatment of disorders associated with endothelin activities such as hypertension, pulmonary hypertension, renal hypertension, Raynaud disease, bronchial asthma, gastric ulcer, chronic heart failure, etc.

  式[I]的新型磺酰胺衍生物： 其中环 A 和环 B 是取代或未取代的单环、双环或三环烃，或取代或未取代的杂环基团，Q 是单键、-O-、-S-、-SO-、-SO2- 或-CH2-、Y 是-O-、-S-或-NH-，Alk 是低级亚烷基或烯基，Z 是-O-或-NH-，R 是取代或未取代的芳香杂环或芳基，R1 是 H、三氟甲基、取代或未取代的氨基、取代或未取代的低级烷基、取代或未取代的芳香杂环或芳基、取代或未取代的低级烷基、烯基、炔基、取代或未取代的低级烷硫基、或烷氧基、或取代或未取代的杂环或芳基，或其药学上可接受的盐，可用于预防或治疗与内皮素活性相关的疾病，如高血压、肺动脉高压、肾性高血压、雷诺氏病、支气管哮喘、胃溃疡、慢性心力衰竭等。