1--Trifluoracetacetyl-2,4,6-trimethylbenzol | 58529-93-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1--Trifluoracetacetyl-2,4,6-trimethylbenzol
• 英文别名: γ,γ,γ-trichloro-acetoacetylmesitylene；4,4,4-Trichloro-1-(2,4,6-trimethylphenyl)butane-1,3-dione
• CAS: 58529-93-4
• 化学式: C₁₃H₁₃Cl₃O₂
• 分子量: 307.604
• InChiKey: NTEVENNODAKPLF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Pyrone derivatives and method for producing same
  申请人：——

  公开号：US20030013896A1

  公开（公告）日：2003-01-16

  Disclosed is a novel method for producing pyrone derivatives of general formula (I), wherein X 1 means halogen-methyl, whereby an acetoacetic acid derivative of general formula (II), wherein X 1 has the aforementioned meaning and X 2 means chlorine or bromine, is treated with Lewis acid and is subsequently converted into the desired product by means of water.

  本发明公开了一种生产一般式(I)的吡喃衍生物的新方法，其中X1表示卤代甲基，通过将一般式(II)的乙酰乙酸衍生物进行处理，其中X1具有上述含义，X2表示氯或溴，然后用Lewis酸处理，并通过水转化为所需的产物。
• PYRONDERIVATE UND VERFAHREN ZU DEREN HERSTELLUNG
  申请人：Lonza AG

  公开号：EP1235821A2

  公开（公告）日：2002-09-04
• PYRIDINE DERIVATIVES INHIBITING ANGIOGENESIS AND/OR VEGF RECEPTOR TYROSINE KINASE
  申请人：Novartis AG

  公开号：EP1254138A1

  公开（公告）日：2002-11-06
• US6716999B2
  申请人：——

  公开号：US6716999B2

  公开（公告）日：2004-04-06
• [EN] PYRIDINE DERIVATIVES INHIBITING ANGIOGENESIS AND/OR VEGF RECEPTOR TYROSINE KINASE<br/>[FR] DERIVES DE PYRIDINE INHIBANT L'ANGIOGENESE ET/OU LA TYROSINE-KINASE DU RECEPTEUR DE VEGF
  申请人：NOVARTIS AG

  公开号：WO2001058899A1

  公开（公告）日：2001-08-16

  The invention relates to pyridine derivatives of formula (I), wherein the substituents and symbols are defined as indicated in the description, processes for the preparation thereof, their usage in the preparation of a pharmaceutical composition for the treatment of a disease which responds to an inhibition of angiogenesis, and pharmaceutical compositions containing such compounds.