D-2-(6'-isopropylamino-2'-benzothiazolyl)-δ2-thiazoline-4-carboxylic acid | 1055343-35-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D-2-(6'-isopropylamino-2'-benzothiazolyl)-δ2-thiazoline-4-carboxylic acid
• 英文别名: (4S)-2-[6-(propan-2-ylamino)-1,3-benzothiazol-2-yl]-4,5-dihydro-1,3-thiazole-4-carboxylic acid
• CAS: 1055343-35-5
• 化学式: C₁₄H₁₅N₃O₂S₂
• 分子量: 321.424
• InChiKey: XQWYBWPHVQGVKE-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  128
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-氯-6-氨基苯并噻唑 在 三乙酰氧基硼氢化钠 、 溶剂黄146 作用下， 以 甲醇 、 水 、 二甲基亚砜 、 1,2-二氯乙烷 为溶剂， 反应 8.0h， 生成 D-2-(6'-isopropylamino-2'-benzothiazolyl)-δ2-thiazoline-4-carboxylic acid
  参考文献：
  名称：

  Luciferins

  摘要：

  揭示了新型荧光素、制备荧光素的方法以及其用途。

  公开号：

  US20080226557A1

文献信息

• Derivatives and their use as selective inhibitors of caspase-2
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：US10961219B2

  公开（公告）日：2021-03-30

  The present invention relates to a compound of formula (I) wherein P1, P3, P4 and P5 are amino acid residues. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.

  本发明涉及一种式（I）化合物，其中 P1、P3、P4 和 P5 为氨基酸残基。本发明还涉及一种用作 Caspase-2 抑制剂及其治疗用途的式 (I) 化合物。本发明还涉及式（I）化合物作为活性碱基探针选择性检测 Caspase-2 活性的用途。
• Compounds and their use as selective inhibitors of caspase-2
  申请人：UNIVERSITÉ DE PARIS

  公开号：US11407741B2

  公开（公告）日：2022-08-09

  The present invention relates to a compound of formula (I): wherein P1, P3, P4 and P5 are amino acid residues or amino acid like structures. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.

  本发明涉及一种式 (I) 的化合物： 其中 P1、P3、P4 和 P5 为氨基酸残基或类似氨基酸结构。 本发明还涉及一种用作 Caspase-2 抑制剂及其治疗用途的式 (I) 化合物。本发明还涉及式（I）化合物作为活性碱基探针选择性检测 Caspase-2 活性的用途。
• NOVEL DERIVATIVES AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：US20190100508A1

  公开（公告）日：2019-04-04

  The present invention relates to a compound of formula (I) wherein P 1 , P 3 , P 4 and P 5 are amino acid residues. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.
• NOVEL COMPOUNDS AND THEIR USE AS SELECTIVE INHIBITORS OF CASPASE-2
  申请人：UNIVERSITÉ DE PARIS

  公开号：US20200317647A1

  公开（公告）日：2020-10-08

  The present invention relates to a compound of formula (I): wherein P 1 , P 3 , P 4 and P 5 are amino acid residues or amino acid like structures. The invention also relates to a compound of formula (I) for its use as a Caspase-2 inhibitor and for its therapeutical use. It also concerns the use of a compound of formula (I) as activity base probe to selectively detect Caspase-2 activity.