(4aR,6R,7R,8S,8aR)-6-methoxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxine-7,8-diyl bis(7-((tert-butyldimethylsilyl)oxy)-2,2-diphenylbenzo[d][1,3]dioxole-5-carboxylate) | 866330-24-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4aR,6R,7R,8S,8aR)-6-methoxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxine-7,8-diyl bis(7-((tert-butyldimethylsilyl)oxy)-2,2-diphenylbenzo[d][1,3]dioxole-5-carboxylate)
• CAS: 866330-24-7
• 化学式: C₆₆H₇₀O₁₄Si₂
• 分子量: 1143.44
• InChiKey: IQOLWMXAPIQJRO-BFGAMBDLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  14.04
• 重原子数：
  82.0
• 可旋转键数：
  14.0
• 环数：
  11.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  144.9
• 氢给体数：
  0.0
• 氢受体数：
  14.0

反应信息

• 作为反应物：
  描述：

  (4aR,6R,7R,8S,8aR)-6-methoxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxine-7,8-diyl bis(7-((tert-butyldimethylsilyl)oxy)-2,2-diphenylbenzo[d][1,3]dioxole-5-carboxylate) 在 四丁基氟化铵 、 溶剂黄146 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 生成
  参考文献：
  名称：

  O-Methylglucogalloyl esters: Synthesis and evaluation of their antimycotic activity

  摘要：

  The two anomers of O-methyl gluco-2,3-digalloyl esters were synthesized and their antimycotic activity toward yeasts of biomedical importance was evaluated. When used at subinhibitory concentration and regardless of stereochemistry at the anomeric carbon, these compounds enhance the antimycotic activity of Amphotericin B. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.037
• 作为产物：
  描述：

  3,4-(diphenylmethylenedioxy)-5-hydroxybenzoic acid 在 4-二甲氨基吡啶 、 4-(dimethylamino)pyridine hydrochloride 、 溶剂黄146 、 N,N-二异丙基乙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 生成 (4aR,6R,7R,8S,8aR)-6-methoxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxine-7,8-diyl bis(7-((tert-butyldimethylsilyl)oxy)-2,2-diphenylbenzo[d][1,3]dioxole-5-carboxylate)
  参考文献：
  名称：

  O-Methylglucogalloyl esters: Synthesis and evaluation of their antimycotic activity

  摘要：

  The two anomers of O-methyl gluco-2,3-digalloyl esters were synthesized and their antimycotic activity toward yeasts of biomedical importance was evaluated. When used at subinhibitory concentration and regardless of stereochemistry at the anomeric carbon, these compounds enhance the antimycotic activity of Amphotericin B. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.037