Acetic acid [2,7-dimethyl-5H-thiazolo[4,5-d]pyridazin-(4Z)-ylidene]-hydrazide | 184147-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Acetic acid [2,7-dimethyl-5H-thiazolo[4,5-d]pyridazin-(4Z)-ylidene]-hydrazide
• 英文别名: N'-(2,7-dimethyl-[1,3]thiazolo[4,5-d]pyridazin-4-yl)acetohydrazide
• CAS: 184147-68-0
• 化学式: C₉H₁₁N₅OS
• 分子量: 237.285
• InChiKey: WGMDSRXCYPZSIU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  108
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Acetic acid [2,7-dimethyl-5H-thiazolo[4,5-d]pyridazin-(4Z)-ylidene]-hydrazide 在 吡啶 作用下， 反应 1.0h， 以60%的产率得到3,5,7-Trimethyl-6-thia-1,2,3a,4,8-pentaaza-as-indacene
  参考文献：
  名称：

  Synthesis and Biological Evaluation of New Fused Thiazolo[4,5-d] Pyridazine Derivatives

  摘要：

  AbstractThe synthesis of thiazolo[4,5‐d]pyridazines and the unknown ring systems, thiazolo[4,5‐d]‐1,2,4‐triazolo‐ and tetrazolo[4,3‐b]pyridazines as well as thiazolo(4,5‐d]pyridazino[2,3‐c]2H triazines, has been achieved according to different pathways. Biological testing of the new tricyclic heterocycles revealed that some of these compounds possess remarkable antibacterial activity.

  DOI：

  10.1002/jccs.199600062
• 作为产物：
  描述：

  5-乙酰基-2-甲基-4-噻唑羧酸乙酯 在 一水合肼 、 肼 、 三氯氧磷 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 Acetic acid [2,7-dimethyl-5H-thiazolo[4,5-d]pyridazin-(4Z)-ylidene]-hydrazide
  参考文献：
  名称：

  Synthesis and Biological Evaluation of New Fused Thiazolo[4,5-d] Pyridazine Derivatives

  摘要：

  AbstractThe synthesis of thiazolo[4,5‐d]pyridazines and the unknown ring systems, thiazolo[4,5‐d]‐1,2,4‐triazolo‐ and tetrazolo[4,3‐b]pyridazines as well as thiazolo(4,5‐d]pyridazino[2,3‐c]2H triazines, has been achieved according to different pathways. Biological testing of the new tricyclic heterocycles revealed that some of these compounds possess remarkable antibacterial activity.

  DOI：

  10.1002/jccs.199600062