(3S)-7-chloro-3-methyl-1-piperidin-4-yl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one trifluoroacetate | 1268841-64-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3S)-7-chloro-3-methyl-1-piperidin-4-yl-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one trifluoroacetate
• 英文别名: (3S)-7-chloro-3-methyl-1-piperidin-4-ylpyrido[2,3-b][1,4]oxazin-2-one;2,2,2-trifluoroacetic acid
• CAS: 1268841-64-0
• 化学式: C₂HF₃O₂*C₁₃H₁₆ClN₃O₂
• 分子量: 395.766
• InChiKey: MBQULPTWQFJHTP-QRPNPIFTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  91.8
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• 3-(BIARYOXY)PROPIONIC ACID DERIVATIVE
  申请人：Nishi Tatsuya

  公开号：US20120245152A1

  公开（公告）日：2012-09-27

  A compound of the general formula (I): [wherein, R 1 represents a halogen atom, or the like, R 2 represents a hydrogen atom, or the like, R 3 and R 4 , each independently, represent a hydrogen atom, a C 1-4 alkyl group, or the like, R 5 represents a hydrogen atom, a halogen atom, or the like, R 6 represents a hydrogen atom, a halogen atom, or the like, R 7 and R 8 , each independently, represent a hydrogen atom, a halogen atom, or the like, R 9 and R 10 , each independently, represent a hydrogen atom, a C 1-4 alkyl group, R 11 and R 12 , each independently, represent a hydrogen atom, a C 1-4 alkyl group, or the like, X represents an oxygen atom, a group —CH 2 —, or the like, Y represents a nitrogen atom, a group ═CH—, or the like, and Z represents a nitrogen atom, or the like] or a pharmacologically acceptable salt thereof, which has an excellent suppressive action on platelet aggregation, and is useful for prevention and/or treatment of thromboembolism.

  一种具有一般式（I）的化合物：[其中，R1代表卤素原子或类似物，R2代表氢原子或类似物，R3和R4各自独立地代表氢原子、C1-4烷基或类似物，R5代表氢原子、卤素原子或类似物，R6代表氢原子、卤素原子或类似物，R7和R8各自独立地代表氢原子、卤素原子或类似物，R9和R10各自独立地代表氢原子、C1-4烷基，R11和R12各自独立地代表氢原子、C1-4烷基或类似物，X代表氧原子、-CH2-基团或类似物，Y代表氮原子、═CH-基团或类似物，Z代表氮原子或类似物]或其药学上可接受的盐，具有出色的抑制血小板聚集作用，可用于预防和/或治疗血栓栓塞。
• 3-(BIARYLOXY) PROPIONIC ACID DERIVATIVE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2471792A1

  公开（公告）日：2012-07-04

  A compound of the general formula (I): [wherein, R1 represents a halogen atom, or the like, R2 represents a hydrogen atom, or the like, R3 and R4, each independently, represent a hydrogen atom, a C1-4 alkyl group, or the like, R5 represents a hydrogen atom, a halogen atom, or the like, R6 represents a hydrogen atom, a halogen atom, or the like, R7 and R8, each independently, represent a hydrogen atom, a halogen atom, or the like, R9 and R10, each independently, represent a hydrogen atom, a C1-4 alkyl group, R11 and R12, each independently, represent a hydrogen atom, a C1-4 alkyl group, or the like, X represents an oxygen atom, a group -CH2-, or the like, Y represents a nitrogen atom, a group =CH-, or the like, and Z represents a nitrogen atom, or the like] or a pharmacologically acceptable salt thereof, which has an excellent suppressive action on platelet aggregation, and is useful for prevention and/or treatment of thromboembolism.

  通式(I)的化合物： [其中，R1 代表卤原子或类似物，R2 代表氢原子或类似物，R3 和 R4 各自独立地代表氢原子、C1-4 烷基或类似物，R5 代表氢原子、卤原子或类似物，R6 代表氢原子、卤原子或类似物，R7 和 R8 各自独立地代表氢原子、卤原子或类似物，R9 和 R10 各自独立地代表氢原子、R11和R12各自独立地代表氢原子、C1-4烷基或类似基团，X代表氧原子、基团-CH2-或类似基团，Y代表氮原子、基团=CH-或类似基团，Z代表氮原子或类似基团]或其药理上可接受的盐，对血小板聚集有很好的抑制作用，可用于预防和/或治疗血栓栓塞。
• US8729095B2
  申请人：——

  公开号：US8729095B2

  公开（公告）日：2014-05-20