4-Methyl-2-methylene-3-oxo-pentanenitrile | 22163-79-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-Methyl-2-methylene-3-oxo-pentanenitrile
• 英文别名: 4-Methyl-2-methylidene-3-oxopentanenitrile
• CAS: 22163-79-7
• 化学式: C₇H₉NO
• 分子量: 123.155
• InChiKey: MPKCABBIXMZZRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  40.9
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR
  申请人：Bifulco, Jr. Neil

  公开号：US20150119405A1

  公开（公告）日：2015-04-30

  Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

  本处描述的是FGFR-4的抑制剂，包括含有此类化合物的药物组合物，以及使用此类化合物和组合物的方法。
• Inhibitors of the fibroblast growth factor receptor
  申请人：BLUEPRINT MEDICINES CORPORATION

  公开号：US10000490B2

  公开（公告）日：2018-06-19

  Described herein are inhibitors of FGFR-4, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of FGFR-4.

  本文描述了 FGFR-4 的抑制剂、包括此类化合物的药物组合物以及使用此类化合物和组合物抑制 FGFR-4 活性的方法。
• Substituted inhibitors of menin-MLL and methods of use
  申请人：Kura Oncology, Inc.

  公开号：US10781218B2

  公开（公告）日：2020-09-22

  The present disclosure provides compounds of Formula (II-A), which inhibit the interaction of menin with one or more of MLL1, MLL2 and MLL-fusion oncoproteins. Also disclosed are methods for the treatment of leukemia, solid cancers, diabetes and other diseases dependent on activity of MLL1, MLL2, MLL fusion proteins, and/or menin.

  本公开提供了式 (II-A) 的化合物、 其可抑制 menin 与 MLL1、MLL2 和 MLL 融合肿瘤蛋白中的一种或多种的相互作用。还公开了治疗白血病、实体癌、糖尿病和其他依赖于 MLL1、MLL2、MLL 融合蛋白和/或 menin 活性的疾病的方法。
• METHOD FOR SCREENING INHIBITORS OF RAS
  申请人：Araxes Pharma LLC

  公开号：US20170131278A1

  公开（公告）日：2017-05-11

  Provided herein are compositions, reactions mixtures, mutant Ras proteins, kits, substrates, and systems for selecting a Ras antagonist, as well as methods of using the same.
• THIENOPYRIMIDINE AND THIENOPYRIDINE COMPOUNDS AND METHODS OF USE THEREOF
  申请人：The Regents of the University of Michigan

  公开号：US20170247391A1

  公开（公告）日：2017-08-31

  The present disclosure provides compounds and methods for inhibiting the interaction of menin with its upstream or downstream signaling molecules including but not limited to MLL1, MLL2 and MLL-fusion oncoproteins. Compounds of the disclosure may be used in methods for the treatment of a wide variety of cancers and other diseases associated with one or more of MLL1, MLL2, MLL fusion proteins, and menin.