3-Hydroxy-2-(2,3,4-trihydroxyphenyl)-4H-chromen-4-one | 649552-06-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-Hydroxy-2-(2,3,4-trihydroxyphenyl)-4H-chromen-4-one
• 英文别名: 3-hydroxy-2-(2,3,4-trihydroxyphenyl)chromen-4-one
• CAS: 649552-06-7
• 化学式: C₁₅H₁₀O₆
• 分子量: 286.24
• InChiKey: DTOSMSVKBWNCSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Sirtuin polymorphisms and methods of use thereof
  申请人：Laakso Markku

  公开号：US20080249103A1

  公开（公告）日：2008-10-09

  Provided herein are methods for diagnosis and prognosis using polymorphic variants of sirtuins. Such polymorphic may be used, for example, to identify subjects that would be responsive to treatment with a sirtuin modulating compound and/or subjects that are suffering from or susceptible to a disease mediated by a sirtuin. Also provided are methods for determining the predictive value of a sirtuin polymorphic variant, methods for evaluating sirtuin modulating compounds, and methods for determining appropriate dosage and/or treatment regimens for subjects having one or more sirtuin polymorphic variants. Screening methods for identifying sirtuin modulating compounds using polymorphic variants of a sirtuin are also provided.

  本文提供了使用sirtuins的多态性变体进行诊断和预后的方法。这种多态性可能被用来识别对sirtuin调节化合物治疗有响应的受试者，以及患有或易受sirtuin介导疾病影响的受试者。还提供了确定sirtuin多态性变体预测价值的方法，评估sirtuin调节化合物的方法，以及确定具有一个或多个sirtuin多态性变体的受试者的适当剂量和/或治疗方案的方法。还提供了使用sirtuin的多态性变体筛选识别sirtuin调节化合物的筛选方法。
• [EN] SMALL MOLECULE CD38 INHIBITORS AND METHODS OF USING SAME<br/>[FR] INHIBITEURS DE CD38 À PETITES MOLÉCULES ET LEURS PROCÉDÉS D'UTILISATION
  申请人：HARVARD COLLEGE

  公开号：WO2013002879A1

  公开（公告）日：2013-01-03

  The invention provides methods and compositions for inhibiting CD 38 activity, and methods of treating or preventing various disorders associated with CD38 activity.

  这项发明提供了抑制CD38活性的方法和组合物，以及治疗或预防与CD38活性相关的各种疾病的方法。
• BIOMARKERS OF SIRTUIN ACTIVITY AND METHODS OF USE THEREOF
  申请人：Boss Olivier

  公开号：US20100215632A1

  公开（公告）日：2010-08-26

  Provided are methods for monitoring sirtuin modulation in a subject, for example, during therapeutic treatment with a sirtuin modulating compound. The methods involve determining the expression level of one or more sirtuin biomarkers in a biological sample from the subject. Also provided are methods for identifying compounds that modulate the activity of a sirtuin protein using one or more sirtuin biomarkers.

  提供了一种监测主体中sirtuin调节的方法，例如，在使用sirtuin调节化合物进行治疗期间。该方法涉及确定来自主体生物样本中一个或多个sirtuin生物标志物的表达水平。还提供了一种使用一个或多个sirtuin生物标志物识别调节sirtuin蛋白活性的化合物的方法。
• [EN] COMPOSITIONS AND METHODS FOR TREATING METABOLIC DISORDERS<br/>[FR] COMPOSITIONS ET MÉTHODES POUR LE TRAITEMENT DE TROUBLES MÉTABOLIQUES
  申请人：NUSIRT SCIENCES INC

  公开号：WO2018058109A1

  公开（公告）日：2018-03-29

  Methods and compounds useful for reducing, treating, preventing, or sustaining the reduction of a metabolic disease or disorder are provided herein. Also provided herein are compositions and kits for practicing any of the methods described herein.

  本文提供了用于减少、治疗、预防或维持代谢性疾病或紊乱的方法和化合物。本文还提供了用于实施本文中描述的任何方法的组合物和工具包。
• Cyclohexyl carbamate compounds as anti-ageing actives
  申请人：Symrise AG

  公开号：EP2389922A1

  公开（公告）日：2011-11-30

  The present invention relates to the cosmetic, dermatological or therapeutic use of compounds of formula (I) given below, in particular as anti-ageing actives. wherein A denotes wherein X, Y and Z independently of one another denote hydrogen, C1-C4-alkyl or C2-C4-alkenyl, wherein optionally two of the radicals X, Y and Z are covalently bonded to one another under formation of a bicyclic ring system, in such a bicyclic ring system two of the radicals X, Y and Z together preferably form a radical having 1 to 4 carbon atoms, preferably a hydrocarbon radical having 1 to 3 carbon atoms, B denotes NR1R2, wherein R1 denotes hydrogen or an organic radical having 1 to 14 carbon atoms, R2 denotes an organic radical having 1 to 14 carbon atoms, and wherein optionally R1 and R2 are covalently bonded to one another, preferably so that B is a 3 to 8 membered ring. The invention further relates to corresponding methods and to compositions and cosmetic, dermatological or pharmaceutical preparations (compositions) comprising one or more compounds of formula (I) and one or more further anti-ageing actives. The invention further relates to compounds of formula (I) as a drug, their use for the preparation of a pharmaceutical composition and to certain novel compounds of formula (I).

  本发明涉及以下式子(I)的化合物在化妆品、皮肤科或治疗中的使用，特别是作为抗衰老活性物质。 其中， A代表 其中，X、Y和Z分别独立地表示氢、C1-C4烷基或C2-C4烯基， 其中，可选地，X、Y和Z中的两个基团在形成二环环系的同时共价键合在一起，这样，在这样的二环环系中，X、Y和Z中的两个基团一起优选形成具有1到4个碳原子的基团，优选是指1到3个碳原子的碳氢基团， B代表NR1R2， 其中， R1代表氢或具有1到14个碳原子的有机基团， R2代表具有1到14个碳原子的有机基团， 并且可选地，R1和R2共价键合在一起，优选是使B成为3到8成员环。 本发明还涉及相应的方法、包含一个或多个式(I)化合物和一个或多个进一步的抗衰老活性物质的组合物和化妆品、皮肤科或制药制剂(组合物)。本发明还涉及式(I)化合物作为药物、其用于制备制药组合物以及某些新的式(I)化合物。