cis-4-ethylcyclohexanemethanol | 75839-85-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: cis-4-ethylcyclohexanemethanol
• CAS: 75839-85-9
• 化学式: C₉H₁₈O
• 分子量: 142.241
• InChiKey: YSQZCEWPPUAANL-DTORHVGOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10.0
• 可旋转键数：
  2.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  methyl cis and trans-4-ethylcyclohexanecarboxylate 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 反应 0.17h， 生成 trans-4-ethyl-cyclohexanemethanol 、 cis-4-ethylcyclohexanemethanol
  参考文献：
  名称：

  Booth, Harold; Everett, Jeremy Ramsey, Canadian Journal of Chemistry, 1980, vol. 58, p. 2714 - 2719

  摘要：

  DOI：

文献信息

• [EN] HETEROARYL COMPOUNDS AS IRAK INHIBITORS AND USES THEREOF<br/>[FR] COMPOSÉS HÉTÉROARYLES SERVANT D'INHIBITEURS D'IRAK, ET LEURS UTILISATIONS
  申请人：MERCK PATENT GMBH

  公开号：WO2017049068A1

  公开（公告）日：2017-03-23

  The present invention relates to compounds of Formula (I) and pharmaceutically acceptable compositions thereof, useful as IRAK inhibitors.

  本发明涉及式(I)化合物及其药用可接受的组合物，作为IRAK抑制剂。
• CHROMAN DERIVATIVES AS TRPM8 INHIBITORS
  申请人：AMGEN INC.

  公开号：US20140045855A1

  公开（公告）日：2014-02-13

  Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure: where the definitions of the variables are provided herein.

  Formula I的Chroman化合物和衍生物是TRPM8的有用抑制剂。这些化合物在治疗多种由TRPM8介导的疾病和症状方面具有用途，并可用于制备治疗这些疾病和症状的药物和药物组合物。这些疾病的例子包括，但不限于，偏头痛和神经病性疼痛。Formula I的化合物具有以下结构：变量的定义在此提供。
• Novel Methyl-Piperidine Compounds Useful for Inhibiting Microsomal Prostaglandin E2 Synthase-1
  申请人：Eli Lilly and Company

  公开号：US20170326128A1

  公开（公告）日：2017-11-16

  The present invention provides compounds of Formula (1), or a pharmaceutically acceptable salt thereof, formula (1), where R, R1, and G are as described herein; methods of preparing the compounds; and use of the compounds to treat pain and/or inflammation associated with arthritis or osteoarthritis.
• US8952009B2
  申请人：——

  公开号：US8952009B2

  公开（公告）日：2015-02-10
• [EN] NOVEL METHYL-PIPERIDINE COMPOUNDS USEFUL FOR INHIBITING MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1<br/>[FR] NOUVEAUX COMPOSÉS MÉTHYL-PIPÉRIDINE SERVANT À INHIBER LA PROSTAGLANDINE E2 SYNTHASE-1 MICROSOMALE
  申请人：LILLY CO ELI

  公开号：WO2016069376A1

  公开（公告）日：2016-05-06

  The present invention provides compounds of Formula (1), or a pharmaceutically acceptable salt thereof, formula (1), where R, R1, and G are as described herein; methods of preparing the compounds; and use of the compounds to treat pain and/or inflammation associated with arthritis or osteoarthritis.