2'-Desoxy-8-jod-adenosin | 17318-15-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 2'-Desoxy-8-jod-adenosin
• 英文别名: 8-iodo-2'-deoxy-adenosine；(2R,3S,5R)-5-(6-amino-8-iodopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
• CAS: 17318-15-9
• 化学式: C₁₀H₁₂IN₅O₃
• 分子量: 377.141
• InChiKey: RSGUOHXUVLCJOY-KVQBGUIXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] MODIFIED NUCLEOSIDES<br/>[FR] NUCLÉOSIDES MODIFIÉS
  申请人：UNIV KONSTANZ

  公开号：WO2017097973A1

  公开（公告）日：2017-06-15

  The present invention relates to modified nucleosides which are linked to cargo molecules and which can be incorporated by DNA or RNA polymerases in strand synthesis. The present invention also relates to use of such modified nucleosides as substrates for DNA or RNA polymerases. The present invention also relates to the use of such modified nucleosides in diagnosis and prognosis of diseases or disorders associated with a target sequence. The present invention also relates to methods for producing such modified nucleosides, kits comprising such nucleosides, and in vitro methods for diagnosing or predicting diseases or disorders associated with a target sequence. The present invention also relates to modified nucleosides for use in diagnosing, predicting or treating diseases or disorders associated with a target sequence.

  本发明涉及与载荷分子连接的修饰核苷，可以由DNA或RNA聚合酶在链合成中合并。本发明还涉及将这种修饰核苷用作DNA或RNA聚合酶的底物的用途。本发明还涉及将这种修饰核苷用于诊断和预测与靶序列相关的疾病或紊乱的用途。本发明还涉及生产这种修饰核苷的方法，包括这种核苷的试剂盒，以及用于诊断或预测与靶序列相关的疾病或紊乱的体外方法。本发明还涉及用于诊断、预测或治疗与靶序列相关的疾病或紊乱的修饰核苷。
• METHOD FOR DIAGNOSING DISEASES USING MULTIPLEX FLUORESCENCE AND SEQUENCING
  申请人：MultiplexDX, s.r.o.

  公开号：EP3775277A1

  公开（公告）日：2021-02-17
• MICRORNA INHIBITORS FOR USE IN TREATING METABOLIC DISEASES
  申请人：Helmholtz Zentrum München Forschungszentrum für Gesundheit und Umwelt GmbH

  公开号：EP3850099A1

  公开（公告）日：2021-07-21
• [EN] MICRORNA INHIBITORS FOR USE IN TREATING METABOLIC DISEASES<br/>[FR] INHIBITEURS DE MICRO-ARN A UTILISER DANS LE TRAITEMENT DES MALADIES MÉTABOLIQUES
  申请人：HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM GESUNDHEIT & UMWELT GMBH

  公开号：WO2020053186A1

  公开（公告）日：2020-03-19

  The present invention relates to composition comprising an inhibitor of miR-379 or a portion or fragment thereof and an inhibitor of miR-541 or a portion or fragment thereof, and/or an inhibitor of the target site of miR-379 or a portion or fragment thereof and an inhibitor of the target site of miR-541 or a portion or fragment thereof, and/or a combination of an inhibitor of miR-379 or a portion or fragment thereof and an inhibitor of the target site of miR-541 or a portion or fragment thereof or a combination of an inhibitor of the target site of miR-379 or a portion or fragment thereof and an inhibitor of miR-541 or a portion or fragment thereof. The present invention also relates to the respective composition for use in treating or preventing a metabolic disease, a disease related to a metabolic disorder, and/or cancer.
• [EN] METHOD FOR DIAGNOSING DISEASES USING MULTIPLEX FLUORESCENCE AND SEQUENCING<br/>[FR] PROCÉDÉ DE DIAGNOSTIC DE MALADIES PAR FLUORESCENCE ET SÉQUENÇAGE MULTIPLEX
  申请人：MULTIPLEX DX

  公开号：WO2020070325A1

  公开（公告）日：2020-04-09

  The present invention relates to methods for diagnosing a disease by determining via multiplex fluorescence in situ hybridization (FISH) whether or not mRNA species and/or at least one miRNA species of disease-associated biomarkers are present in a sample obtained from a subject, and by determining by multiplex sequencing whether or not said mRNA species of disease-associated biomarkers and/or said miRNA species of disease-associated biomarkers of step(a) are present in said sample. The present invention also relates to kits for performing the methods for diagnosis as described and provided herein as well as use of such kits for performing the methods for diagnosis as described and provided herein.