2-(1-cyclobutyl-piperidin-4-yloxy)-5-methanesulfonyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridine | 1363258-91-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(1-cyclobutyl-piperidin-4-yloxy)-5-methanesulfonyl-6,7-dihydro-4H-thiazolo[5,4-c]pyridine
• 英文别名: 2-(1-cyclobutylpiperidin-4-yl)oxy-5-methylsulfonyl-6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridine
• CAS: 1363258-91-6
• 化学式: C₁₆H₂₅N₃O₃S₂
• 分子量: 371.525
• InChiKey: GECQXBVQNJEQHM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.81
• 拓扑面积：
  99.4
• 氢给体数：
  0
• 氢受体数：
  7

文献信息

• HETEROCYCLYL COMPOUNDS AS HISTAMINE H3 RECEPTOR LIGANDS
  申请人：Nirogi Ramakrishna

  公开号：US20140148440A1

  公开（公告）日：2014-05-29

  The present invention relates to heterocyclyl compounds of formula (I), and their pharmaceutically acceptable salts and compositions containing them. The present invention also relates to a process for the preparation of above said novel compounds, and their pharmaceutically acceptable salts. The compounds of formula (I) are useful in the treatment of various disorders that are related to Histamine H 3 receptors, for example cognitive disorders, sleep disorders, obesity and pain.

  本发明涉及式（I）的杂环化合物及其药学上可接受的盐和含有它们的组合物。本发明还涉及上述新型化合物及其药学上可接受的盐的制备方法。式（I）的化合物在治疗与组胺H3受体相关的各种疾病方面具有用途，例如认知障碍、睡眠障碍、肥胖症和疼痛。
• US8912179B2
  申请人：——

  公开号：US8912179B2

  公开（公告）日：2014-12-16