4'-乙基联苯-4-醇 | 21345-28-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4'-乙基联苯-4-醇
• 中文别名: 4’-乙基联苯-4-醇；4-(4-乙基苯基)苯酚
• 英文名称: 4'-ethyllbiphenyl-4-ol
• 英文别名: 4-(p-Ethylphenyl)-phenol；4'-ethylbiphenyl-4-ol；4-(4-Ethylphenyl)phenol
• CAS: 21345-28-8
• 化学式: C₁₄H₁₄O
• 分子量: 198.265
• InChiKey: MVHOIHXEJQPTQT-UHFFFAOYSA-N

物化性质

• 熔点：
  151 °C
• 沸点：
  329.9±21.0 °C(Predicted)
• 密度：
  1.066±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2907199090
• 危险性防范说明：
  P261,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  4'-乙基联苯-4-醇 在 palladium on activated charcoal sodium hydroxide 、 potassium tert-butylate 、 氢气 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 反应 3.0h， 生成 2-Cyclopentyloxy-3-{4-[2-(4'-ethyl-biphenyl-4-yloxy)-ethoxy]-phenyl}-propionic acid
  参考文献：
  名称：

  Design, synthesis, and evaluation of 2-alkoxydihydrocinnamates as PPAR agonists

  摘要：

  A series of 2-alkoxydihydrocinnamates were synthesized as PPAR gamma and PPAR alpha dual agonists. In vitro studies in cell model showed that these compounds were efficacious. Compound 1g was found to be a potent PPAR alpha/gamma dual agonist and will be further evaluated for the treatment of type II diabetes. (c) 2006 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmcl.2005.10.104
• 作为产物：
  描述：

  4-[4-(2-Hydroxyethyl)phenyl]phenol 在 锰 、 氯化镍二甲氧基乙烷 、 1,1,3,3-四甲基二硅氧烷 、 potassium tert-butylate 、 1,3-bis(cyclohexyl)imidazolium tetrafluoroborate 作用下， 以 甲苯 为溶剂， 反应 5.0h， 以80%的产率得到4'-乙基联苯-4-醇
  参考文献：
  名称：

  镍催化的不同碳氧键官能团的还原脱氧

  摘要：

  我们报告了一种用于各种含 C-O 键官能团的直接脱氧的催化方法。使用 Ni(II) 预催化剂和硅烷还原剂，醇、环氧化物和醚被还原为相应的烷烃。包括醛和酮在内的不饱和物质也通过中间体甲硅烷基化醇的初始形成而脱氧。该反应对 C(sp 3 )-O 键具有化学选择性，而胺、苯胺、芳基醚、烯烃和含氮杂环不受影响。催化氘化、苄醚脱保护和生物质衍生原料的价值化的应用证明了该方法的一些实际方面。

  DOI：

  10.1021/acscatal.1c03980

文献信息

• SOLUBLE GUANYLATE CYCLASE ACTIVATORS
  申请人：Bittner Amy R.

  公开号：US20090209556A1

  公开（公告）日：2009-08-20

  A compound having the structure useful for treatment or prevention of cardiovascular diseases, endothelial dysfunction, diastolic dysfunction, atherosclerosis, hypertension, angina pectoris, thromboses, restenoses, myocardial infarction, strokes, cardiac insufficiency, pulmonary hypertonia, erectile dysfunction, asthma bronchiale, chronic kidney insufficiency, diabetes, or cirrhosis of the liver in a human or animal patient.

  具有治疗或预防心血管疾病、内皮功能障碍、舒张功能障碍、动脉硬化、高血压、心绞痛、血栓形成、再狭窄、心肌梗死、中风、心脏衰竭、肺动脉高压、勃起功能障碍、支气管哮喘、慢性肾功能不全、糖尿病或人或动物患者肝硬化的化合物的结构。
• Strongly Chemiluminescent Acridinium Esters under Neutral Conditions: Synthesis, Properties, Determination, and Theoretical Study
  作者：Manabu Nakazono、Yuji Oshikawa、Mizuho Nakamura、Hidehiro Kubota、Shinkoh Nanbu

  DOI：10.1021/acs.joc.6b02748

  日期：2017.3.3

  mechanism was composed of the nucleophilic addition reaction of hydroperoxide anion, dioxetanone ring formation, and nonadiabatic transition due to spin–orbit coupling around the transition state (TS) to the triplet state (T1) following the decomposition pathway. The TS which appeared in the thermal decomposition would be a rate-determining step for all three processes.

  合成了具有苯基和联苯基部分的各种新型a啶鎓酯衍生物，并研究了它们的最佳化学发光条件。发现了几种在中性条件下强烈化学发光的cri啶鎓酯，然后将这些衍生物用于检测过氧化氢和葡萄糖。具有强吸电子基团如氰基，甲氧羰基，和硝基在苯基部分的4-位上的苯基-10-甲基吖啶10λ酯4吖啶-9-羧酸盐三氟甲磺酸显示出强的化学发光强度。的化学发光强度3,4-二氰基苯基-10-甲基10λ 4吖啶-9-羧酸盐三氟甲磺酸较苯基-10-甲基10λ的强约100倍4在pH为7的过氧化氢和葡萄糖的线性校准范围吖啶-9-羧酸盐三氟甲磺酸使用0.05〜10 mM和10-2000μM3,4-（二甲氧基羰基）苯基-10-甲基10λ 4 -acridine- 9-羧酸盐三氟甲磺酸盐分别在pH 7和pH 7.5下。通过密度泛函理论的量子化学计算，评价了proposed啶鎓酯通过二氧杂环丁酮结构的化学发光反应机理。所提出的机理是由氢过氧
• Palladium Supported on Zinc Oxide Nanoparticles as Efficient Heterogeneous Catalyst for<i>SuzukiMiyaura</i>and<i>Hiyama</i>Reactions under Normal Laboratory Conditions
  作者：Mona Hosseini-Sarvari、Zahra Razmi

  DOI：10.1002/hlca.201400331

  日期：2015.6

  Nanoscale Pd supported on ZnO was prepared by a facile coprecipitation method. Pd/ZnO Nanoparticles were characterized by using XRD, TEM, SEM, XPS, BET specific surface area measurement, and thermogravimetric analysis. This catalyst was used as novel and excellent heterogeneous catalyst for ligand‐free CC bond‐formation particularly in the synthesis of unsymmetrical biaryls by SuzukiMiyaura and Hiyama

  ZnO负载的纳米级Pd通过简便的共沉淀法制备。通过使用XRD，TEM，SEM，XPS，BET比表面积测量和热重分析对Pd / ZnO纳米颗粒进行了表征。该催化剂用作游离配位体-C新颖和优良的非均相催化剂 C键-形成特别是在由非对称联芳基合成铃木宫浦和桧山交叉偶合在空气气氛下的反应不使用任何的Ar或N的2流动。催化剂可以被回收和再循环几次而没有明显的活性损失。
• ISOCYANATE PRODUCTION PROCESS
  申请人：Shinohata Masaaki

  公开号：US20110092731A1

  公开（公告）日：2011-04-21

  An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without using phosgene. The present invention discloses a process for producing an isocyanate by subjecting a carbamic acid ester to a thermal decomposition reaction, including the steps of: recovering a low boiling point component in a form of a gaseous phase component from a thermal decomposition reaction vessel in which the thermal decomposition reaction is carried out; recovering a liquid phase component containing a carbamic acid ester from a bottom of the thermal decomposition reaction vessel; and supplying all or a portion of the liquid phase component to an upper portion of the thermal decomposition reaction vessel.

  本发明的一个目的是提供一种能够在长时间内稳定地高产且不使用光气的情况下生产异氰酸酯的方法，而不会遇到先前生产异氰酸酯时的问题。本发明公开了一种通过将氨基甲酸酯经受热分解反应来生产异氰酸酯的方法，包括以下步骤：从进行热分解反应的反应釜中回收形成气相组分的低沸点组分；从热分解反应釜底部回收含有氨基甲酸酯的液相组分；并将全部或部分液相组分供给至热分解反应釜的上部。
• PROCESS FOR PRODUCING ISOCYANATES USING DIARYL CARBONATE
  申请人：Shinohata Masaaki

  公开号：US20110054211A1

  公开（公告）日：2011-03-03

  An object of the present invention is to provide a process that enables isocyanate to be produced stably over a long period of time and at high yield without encountering problems of the prior art during production of isocyanate without using phosgene. The present invention provides an isocyanate production process including the steps of: obtaining a reaction mixture containing an aryl carbamate having an aryl group originating in a diaryl carbonate, an aromatic hydroxy compound originating in a diaryl carbonate, and a diaryl carbonate, by reacting a diaryl carbonate and an amine compound in the presence of a reaction solvent in the form of an aromatic hydroxy compound; transferring the reaction mixture to a thermal decomposition reaction vessel; and obtaining isocyanate by applying the aryl carbamate to a thermal decomposition reaction, wherein the reaction vessel in which the reaction between the diaryl carbonate and the amine compound is carried out and the thermal decomposition reaction vessel for the aryl carbamate are different.

  本发明的一个目的是提供一种能够在生产异氰酸酯时在长时间内稳定地且高产率地生产异氰酸酯的方法，而不使用光气时遇到先前技术问题的方法。本发明提供了一种异氰酸酯生产方法，包括以下步骤：通过在反应溶剂形式的芳香羟基化合物存在下，通过反应二芳基碳酸酯和胺化合物得到含有源自二芳基碳酸酯的芳基碳酸酯、源自二芳基碳酸酯的芳香羟基化合物和二芳基碳酸酯的反应混合物；将反应混合物转移至热分解反应容器；通过将芳基碳酸酯应用于热分解反应来获得异氰酸酯，其中进行二芳基碳酸酯和胺化合物之间的反应的反应容器和用于芳基碳酸酯的热分解反应的反应容器是不同的。