6-(3-methylbenzylamino)-9-β-D-arabinofuranosylpurine | 65397-91-3

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 6-(3-methylbenzylamino)-9-β-D-arabinofuranosylpurine
• 英文别名: 1-[9-(3-methyl-benzylamino)-purin-9-yl]-β-D-1-deoxy-arabinofuranose；(2R,3S,4S,5R)-2-(hydroxymethyl)-5-[6-[(3-methylphenyl)methylamino]purin-9-yl]oxolane-3,4-diol
• CAS: 65397-91-3
• 化学式: C₁₈H₂₁N₅O₄
• 分子量: 371.396
• InChiKey: WBJVJFOITZTVRG-LJGDNWOOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• [EN] 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF<br/>[FR] 6-ARYL-9-GLYCOSYLPURINES ET LEUR UTILISATION
  申请人：UNIV PALACKEHO

  公开号：WO2016091236A1

  公开（公告）日：2016-06-16

  The present invention provides 6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, wherein Gly represents β-D-arabinofuranosyl or β-D-2´-deoxyribofuranosyl, Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use for regulation, in particular inhibition, of aging in plants in vivo or plant cells in vitro, and for regulation of growth and development of plants in vivo, plant tissues, plant organs and plant cells in vitro..

  本发明提供了通式I的6-芳基-9-糖苷嘌呤及其与碱金属、氨、胺或酸的加合盐，其中Gly代表β-D-阿拉伯呋喃糖苷或β-D-2´-脱氧核糖呋喃糖苷，Ar代表苄基或呋喃甲基，每个都可以是未取代的或被一个或多个，优选一个至三个，羟基、烷基、卤素、烷氧基、氨基、巯基、羧基、氰基、酰胺基、磺酰基、磺胺基、酰基、酰胺基、酰氧基、烷基氨基、二烷基氨基、烷基巯基、三氟甲基、三氟甲氧基等取代基所取代，用于调节植物体内或植物细胞体外的衰老，特别是抑制衰老，并用于调节植物体内、植物组织、植物器官和植物细胞体外的生长和发育。
• 6-aryl-9-glycosylpurines and use thereof
  申请人：UNIVERZITA PALACKEHO V OLOMOUCI

  公开号：US10550144B2

  公开（公告）日：2020-02-04

  6-aryl-9-glycosidpurines of general formula I and pharmaceutically acceptable salts thereof with alkali metals, ammonia, amines, or addition salts with acids, wherein Gly represents β-D-arabinofuranosyl or β-D-2′-deoxyribofuranosyl, Ar represents benzyl or furfuryl, each of which can be unsubstituted or substituted by one or more, preferably one to three, substituents selected from the group comprising hydroxyl, alkyl, halogen, alkoxy, amino, mercapto, carboxyl, cyano, amido, sulfo, sulfamido, acyl, acylamino, acyloxy, alkylamino, dialkylamino, alkylmercapto, trifluoromethyl, trifluoromethoxy, for use for regulation, in particular inhibition, of aging in plants in vivo or plant cells in vitro, and for regulation of growth and development of plants in vivo, plant tissues, plant organs and plant cells in vitro.

  通式 I 的 6-芳基-9-糖苷嘌呤 及其与碱金属、氨、胺或酸的加成盐的药学上可接受的盐，其中 Gly 代表β-D-阿拉伯呋喃糖基或β-D-2′-脱氧核糖基、 烷基氨基、二烷基氨基、烷基巯基、三氟甲基、三氟甲氧基，用于调节（特别是抑制）体内植物或体外植物细胞的衰老，以及调节体内植物、植物组织、植物器官和体外植物细胞的生长和发育。
• 6-ARYL-9-GLYCOSYLPURINES AND USE THEREOF
  申请人：Univerzita Palackého v Olomouci

  公开号：EP3229772A1

  公开（公告）日：2017-10-18